Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | malate dehydrogenase | 0.0274 | 0.8156 | 0.8156 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0315 | 1 | 1 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.0274 | 0.8156 | 0.8156 |
Plasmodium vivax | lactate dehydrogenase | 0.0315 | 1 | 1 |
Entamoeba histolytica | malate dehydrogenase,cytoplasmic, putative | 0.0274 | 0.8156 | 0.71 |
Leishmania major | malate dehydrogenase | 0.0252 | 0.7163 | 0.5538 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0315 | 1 | 1 |
Echinococcus multilocularis | malate dehydrogenase | 0.0252 | 0.7163 | 0.7163 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0274 | 0.8156 | 0.71 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0194 | 0.4516 | 0.5527 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0315 | 1 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0315 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0109 | 0.0699 | 0.0699 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0118 | 0.1086 | 0.1086 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Echinococcus multilocularis | L lactate dehydrogenase | 0.0121 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0118 | 0.1086 | 0.1086 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0315 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0699 | 0.0699 |
Trypanosoma brucei | malate dehydrogenase-related | 0.0194 | 0.4516 | 0.1935 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.0274 | 0.8156 | 0.8156 |
Echinococcus multilocularis | malate dehydrogenase | 0.0252 | 0.7163 | 0.7163 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0252 | 0.7163 | 0.7799 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0699 | 0.0699 |
Brugia malayi | Probable malate dehydrogenase, mitochondrial precursor | 0.0252 | 0.7163 | 0.7163 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0174 | 0.3642 | 0.3642 |
Echinococcus granulosus | L lactate dehydrogenase | 0.0121 | 0.1228 | 0.1228 |
Leishmania major | cytosolic malate dehydrogenase | 0.0274 | 0.8156 | 0.71 |
Trypanosoma brucei | mitochondrial malate dehydrogenase | 0.0252 | 0.7163 | 0.7799 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0315 | 1 | 1 |
Echinococcus granulosus | dual specificity | 0.0174 | 0.3642 | 0.3642 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0315 | 1 | 0.5 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0315 | 1 | 1 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0194 | 0.4516 | 0.1935 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3581 | 0.3581 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Loa Loa (eye worm) | malate dehydrogenase | 0.0252 | 0.7163 | 0.7163 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0109 | 0.0699 | 0.0699 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0315 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3581 | 0.3581 |
Echinococcus multilocularis | roundabout 2 | 0.0109 | 0.0699 | 0.0699 |
Trypanosoma brucei | glycosomal malate dehydrogenase | 0.0252 | 0.7163 | 0.7799 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0315 | 1 | 1 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0315 | 1 | 1 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.0274 | 0.8156 | 0.8156 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0252 | 0.7163 | 0.7799 |
Leishmania major | mitochondrial malate dehydrogenase | 0.0252 | 0.7163 | 0.5538 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0699 | 0.0699 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Echinococcus granulosus | malate dehydrogenase | 0.0252 | 0.7163 | 0.7163 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0315 | 1 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0315 | 1 | 1 |
Leishmania major | malate dehydrogenase, putative | 0.0315 | 1 | 1 |
Brugia malayi | Malate dehydrogenase, cytoplasmic | 0.0274 | 0.8156 | 0.8156 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0194 | 0.4516 | 0.4516 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0315 | 1 | 1 |
Mycobacterium leprae | PROBABLE MALATE DEHYDROGENASE MDH | 0.0274 | 0.8156 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0109 | 0.0699 | 0.0699 |
Chlamydia trachomatis | malate dehydrogenase | 0.0274 | 0.8156 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0315 | 1 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0252 | 0.7163 | 0.7163 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.0274 | 0.8156 | 0.8156 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0315 | 1 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Giardia lamblia | Malate dehydrogenase | 0.0274 | 0.8156 | 0.5 |
Leishmania major | glycosomal malate dehydrogenase | 0.0252 | 0.7163 | 0.5538 |
Trypanosoma brucei | cytosolic malate dehydrogenase | 0.0274 | 0.8156 | 1 |
Mycobacterium ulcerans | malate dehydrogenase | 0.0274 | 0.8156 | 0.5 |
Leishmania major | malate dehydrogenase, putative | 0.0194 | 0.4516 | 0.1374 |
Echinococcus granulosus | twitchin | 0.0095 | 0.0061 | 0.0061 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0274 | 0.8156 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0174 | 0.3642 | 0.3642 |
Plasmodium falciparum | malate dehydrogenase | 0.0315 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0315 | 1 | 1 |
Echinococcus granulosus | malate dehydrogenase | 0.0252 | 0.7163 | 0.7163 |
Mycobacterium tuberculosis | Probable malate dehydrogenase Mdh | 0.0274 | 0.8156 | 0.5 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0315 | 1 | 1 |
Trypanosoma cruzi | mitochondrial malate dehydrogenase, putative | 0.0252 | 0.7163 | 0.7799 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0175 | 0.3658 | 0.4473 |
Echinococcus multilocularis | dual specificity | 0.0174 | 0.3642 | 0.3642 |
Loa Loa (eye worm) | malate dehydrogenase | 0.0274 | 0.8156 | 0.8156 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0174 | 0.3642 | 0.3642 |
Schistosoma mansoni | malate dehydrogenase | 0.0274 | 0.8156 | 0.8156 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0252 | 0.7163 | 0.7799 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 12 nM | Antimalarial activity against Plasmodium falciparum 3D7 | ChEMBL. | 17722901 |
ED50 (functional) | = 12 nM | Antimalarial activity against Plasmodium falciparum 3D7 | ChEMBL. | 17722901 |
ED50 (functional) | = 16 nM | Antimalarial activity against Plasmodium falciparum K1 | ChEMBL. | 17722901 |
ED50 (functional) | = 16 nM | Antimalarial activity against Plasmodium falciparum K1 | ChEMBL. | 17722901 |
Inhibition (binding) | = 67 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 0.5 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Inhibition (binding) | = 91 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 5 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Inhibition (binding) | = 95 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 50 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.