Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 5 | 260 aa | 307 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1724 | 0.1422 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0054 | 0.1826 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0054 | 0.1826 | 0.1528 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0054 | 0.1826 | 0.1528 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0054 | 0.1826 | 0.1528 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0054 | 0.1826 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.028 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0054 | 0.1826 | 0.1528 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0015 | 0.0389 | 0.0038 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.1826 | 0.1528 |
Plasmodium vivax | protein kinase Crk2 | 0.0054 | 0.1826 | 0.5 |
Onchocerca volvulus | 0.028 | 1 | 1 | |
Plasmodium falciparum | protein kinase 5 | 0.0054 | 0.1826 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0014 | 0.0352 | 0.000000066001 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0014 | 0.0352 | 0.000000066001 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0016 | 0.0454 | 0.0106 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.1826 | 0.1528 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0054 | 0.1826 | 0.1528 |
Brugia malayi | olfactory channel protein osm-9 | 0.0015 | 0.0389 | 0.0038 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0054 | 0.1826 | 0.1528 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0054 | 0.1826 | 0.5 |
Echinococcus granulosus | calcium activated potassium channel | 0.0016 | 0.0454 | 0.0106 |
Trichomonas vaginalis | CMGC family protein kinase | 0.028 | 1 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0054 | 0.1826 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0352 | 0.000000066001 |
Echinococcus granulosus | cyclin dependent kinase | 0.0054 | 0.1826 | 0.1528 |
Brugia malayi | Protein kinase domain containing protein | 0.0054 | 0.1826 | 0.1528 |
Giardia lamblia | Kinase, CMGC CDK | 0.0054 | 0.1826 | 0.1826 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0352 | 0.000000066001 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0015 | 0.0389 | 0.0038 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0054 | 0.1826 | 0.1528 |
Giardia lamblia | Kinase, CMGC CDK | 0.0054 | 0.1826 | 0.1826 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.028 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.028 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.028 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0014 | 0.0352 | 0.000000066001 |
Onchocerca volvulus | 0.028 | 1 | 1 | |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0389 | 0.0038 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0014 | 0.0352 | 0.000000066001 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.1826 | 0.1528 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0015 | 0.0389 | 0.0038 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0054 | 0.1826 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0054 | 0.1826 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0015 | 0.0389 | 0.0038 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0054 | 0.1826 | 0.1528 |
Brugia malayi | cell division control protein 2 homolog | 0.0054 | 0.1826 | 0.1528 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0054 | 0.1826 | 0.1528 |
Trichomonas vaginalis | CMGC family protein kinase | 0.028 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.1826 | 0.1528 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0054 | 0.1826 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0015 | 0.0389 | 0.0038 |
Schistosoma mansoni | transient receptor potential channel | 0.0014 | 0.0352 | 0.000000066001 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0054 | 0.1826 | 0.1528 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0054 | 0.1826 | 1 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.028 | 1 | 1 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0054 | 0.1826 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0015 | 0.0389 | 0.0038 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0054 | 0.1826 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0054 | 0.1826 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.1826 | 0.1528 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Cytotoxicity against VeroC1008 cells at 6.25 to 50 ug/ml by neutral red uptake assay | ChEMBL. | 17291769 |
IC50 (binding) | = 463 nM | Inhibition of human cdk5/p25 by SPA | ChEMBL. | 17291769 |
IC50 (binding) | = 463 nM | Inhibition of human cdk5/p25 by SPA | ChEMBL. | 17291769 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.