TDR Targets

Basic information

Technical information

TDR Targets ID: 439141
Name: 2,3-dichloro-N-[1-[3-hydroxy-2-(hydroxymethyl )propyl]-2-oxo-3,4-dihydroquinolin-3-yl]-4H-t hieno[3,2-b]pyrrole-5-carboxamide
MW: 468.354 | Formula: C20H19Cl2N3O4S
H donors: 4 H acceptors: 4 LogP: 3.06 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCC(CN1C(=O)C(NC(=O)c2cc3c([nH]2)c(c(s3)Cl)Cl)Cc2c1cccc2)CO
InChi: 1S/C20H19Cl2N3O4S/c21-16-17-15(30-18(16)22)6-12(23-17)19(28)24-13-5-11-3-1-2-4-14(11)25(20(13)29)7-10(8-26)9-27/h1-4,6,10,13,23,26-27H,5,7-9H2,(H,24,28)
InChiKey: LQDLDRYJCVZYKX-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2,3-dichloro-N-[1-(3-hydroxy-2-methylol-propyl)-2-keto-3,4-dihydroquinolin-3-yl]-4H-thieno[3,2-b]pyrrole-5-carboxamide
2,3-dichloro-N-[1-[3-hydroxy-2-(hydroxymethyl)propyl]-2-oxo-3,4-dihydroquinolin-3-yl]-4H-thieno[2,3-d]pyrrole-5-carboxamide
2,3-dichloro-N-[1-(3-hydroxy-2-methylol-propyl)-2-keto-3,4-dihydroquinolin-3-yl]-4H-thieno[2,3-d]pyrrole-5-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.5816	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0549	0.0808
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	7tm_1 domain containing protein	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0497	0.0497
Leishmania major	hypothetical protein, conserved	0.0035	0.0549	0.0467
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0549	1
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	G protein-coupled receptor	0.002	0.0131	0.0131
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0131	0.0407
Echinococcus granulosus	7TM GPCR rhodopsin	0.002	0.0131	0.0407
Schistosoma mansoni	amine GPCR	0.002	0.0131	0.0407
Onchocerca volvulus		0.0035	0.0549	0.1351
Mycobacterium ulcerans	lipase LipD	0.0035	0.0549	0.4347
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0131	0.0407
Leishmania major	C-8 sterol isomerase-like protein	0.0372	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Schistosoma mansoni	biogenic amine receptor	0.002	0.0131	0.0407
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0549	0.4347
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Schistosoma mansoni	ap endonuclease	0.0018	0.0086	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.0549
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.002	0.0131	0.0407
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0719	0.223
Schistosoma mansoni	histamine h1 receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0549	0.0808
Brugia malayi	beta-lactamase family protein	0.0035	0.0549	0.0549
Brugia malayi	neuropeptide F receptor	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0131	0.0407
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0549	0.1703
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0623	0.1931
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus multilocularis	serotonin receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0131	0.0407
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.002	0.0131	0.0131
Echinococcus granulosus	neuropeptide receptor	0.002	0.0131	0.0407
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0086	0.0268
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0549	0.0467
Schistosoma mansoni	amine GPCR	0.002	0.0131	0.0407
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1151	0.3392
Schistosoma mansoni	opsin-like receptor	0.002	0.0131	0.0407
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.3224	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0056	0.1151	1
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0131	0.0407
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.3224	1
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.1151	0.357
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0549	0.0808
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0925	0.0925
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.002	0.0131	0.0407
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0086	0.0268
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0553	0.1488
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0549	0.0808
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0131	0.0407
Schistosoma mansoni	alpha-1 adrenergic receptor	0.002	0.0131	0.0407
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0131	0.0407
Brugia malayi	Dopamine receptor protein 1	0.002	0.0131	0.0131
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0131	0.0407
Echinococcus granulosus	glycogen phosphorylase	0.013	0.3224	1
Schistosoma mansoni	hypothetical protein	0.002	0.0131	0.0407
Echinococcus multilocularis	allatostatin A receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0623	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.0549
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.002	0.0131	0.0407
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Schistosoma mansoni	biogenic amine receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.002	0.0131	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Loa Loa (eye worm)	TYRA-2 protein	0.002	0.0131	0.0131
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.002	0.0131	0.0131
Echinococcus granulosus	allatostatin A receptor	0.002	0.0131	0.0407
Echinococcus granulosus	somatostatin receptor	0.002	0.0131	0.0407
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.002	0.0131	0.0407
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.002	0.0131	0.0407
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0131	0.0407
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.3224	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0086	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0131	0.0407
Brugia malayi	RE15519p	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	g protein coupled receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	G protein-coupled receptor F59B2.13	0.002	0.0131	0.0131
Echinococcus multilocularis	neuropeptide receptor A26	0.002	0.0131	0.0407
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.002	0.0131	0.0407
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0549	0.4347
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Echinococcus granulosus	fmrfamide receptor	0.002	0.0131	0.0407
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	carbohydrate phosphorylase	0.013	0.3224	0.3224
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0372	1	1
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.1151	0.1858
Echinococcus granulosus	dro:myosuppressin receptor	0.002	0.0131	0.0407
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0131	0.0407
Echinococcus granulosus	glycogen phosphorylase	0.013	0.3224	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.002	0.0131	0.0407
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.002	0.0131	0.0407
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0131	0.0407
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0549	0.1703
Echinococcus multilocularis	somatostatin receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.3224	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.002	0.0131	0.0407
Echinococcus granulosus	g protein coupled receptor	0.002	0.0131	0.0407
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0549	0.1703
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.002	0.0131	0.0131
Schistosoma mansoni	glycogen phosphorylase	0.013	0.3224	1
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0549	0.4347
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0131	0.0131
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.002	0.0131	0.0407
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.002	0.0131	0.0407
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0131	0.0407
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0131	0.0407
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0549	0.1475
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0549	0.1475
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0131	0.0407
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	alpha 1A adrenergic receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.0549
Brugia malayi	putative neuropeptide receptor	0.002	0.0131	0.0131
Schistosoma mansoni	amine GPCR	0.002	0.0131	0.0407
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0131	0.0407
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0549	0.0467
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.002	0.0131	0.0407
Schistosoma mansoni	hypothetical protein	0.002	0.0131	0.0407
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0131	0.0407
Onchocerca volvulus		0.0035	0.0549	0.1351
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0925	0.0925
Schistosoma mansoni	amine GPCR	0.002	0.0131	0.0407
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0719	0.223
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0131	0.0131
Brugia malayi	Dopamine receptor protein 2	0.002	0.0131	0.0131
Loa Loa (eye worm)	melatonin receptor type 1A	0.002	0.0131	0.0131
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.3224	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Schistosoma mansoni	hypothetical protein	0.002	0.0131	0.0407
Echinococcus multilocularis	neuropeptide FF receptor 2	0.002	0.0131	0.0407
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0623	0.1931
Schistosoma mansoni	neuropeptide receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0131	0.0407
Brugia malayi	GnHR receptor homolog	0.002	0.0131	0.0131
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0549	0.0808
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0549	0.1475
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0131	0.0407
Echinococcus granulosus	serotonin receptor	0.002	0.0131	0.0407
Entamoeba histolytica	glycogenphosphorylase, putative	0.0056	0.1151	0.3392
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0549	0.0808
Brugia malayi	Tachykinin-like peptides receptor 99D	0.002	0.0131	0.0131
Echinococcus multilocularis	neuropeptide s receptor	0.002	0.0131	0.0407
Brugia malayi	G-protein coupled receptor	0.002	0.0131	0.0131
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.002	0.0131	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.002	0.0131	0.0407
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.002	0.0131	0.0407
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0549	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0553	0.1488
Brugia malayi	Serotonin receptor	0.002	0.0131	0.0131
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0549	0.0808
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0086	0.5
Brugia malayi	Melatonin receptor type 1A	0.002	0.0131	0.0131
Brugia malayi	follicle stimulating hormone receptor	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.0549
Echinococcus multilocularis	G protein coupled receptor 139	0.002	0.0131	0.0407
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0131	0.0407
Echinococcus granulosus	neuropeptide FF receptor 2	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0925	0.0925
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0131	0.0407
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0925	0.0925
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.002	0.0131	0.0131
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0372	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0549	0.0808
Onchocerca volvulus		0.0035	0.0549	0.1351
Schistosoma mansoni	neuropeptide receptor	0.002	0.0131	0.0407
Schistosoma mansoni	myosin xvIII	0.002	0.0131	0.0407
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.002	0.0131	0.0131
Echinococcus granulosus	orexin receptor type 2	0.002	0.0131	0.0407
Schistosoma mansoni	biogenic amine receptor	0.002	0.0131	0.0407
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.3224	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.002	0.0131	0.0407
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0549	0.0549
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0086	0.0086
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0086	0.0086
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.3224	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0131	0.0407
Echinococcus granulosus	g protein coupled receptor	0.002	0.0131	0.0407
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0131	0.0407
Echinococcus granulosus	hypothetical protein	0.002	0.0131	0.0407
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0131	0.0407
Echinococcus multilocularis	sex peptide receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0131	0.0407
Echinococcus granulosus	peptide allatostatin:somatostatin	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.019	0.4902	0.4902
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0549	0.1703
Echinococcus multilocularis	dro:myosuppressin receptor	0.002	0.0131	0.0407
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0484	0.0484
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0549	0.4347
Echinococcus multilocularis	orexin receptor type 2	0.002	0.0131	0.0407
Brugia malayi	Serotonin receptor	0.002	0.0131	0.0131
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0497	0.0497
Schistosoma mansoni	opsin-like receptor	0.002	0.0131	0.0407
Echinococcus multilocularis	G-protein coupled receptor, putative	0.002	0.0131	0.0407
Brugia malayi	beta-lactamase family protein	0.0035	0.0549	0.0549
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0086	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0131	0.0407
Echinococcus multilocularis	g-protein coupled receptor	0.002	0.0131	0.0407
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.002	0.0131	0.0407
Brugia malayi	larval opioid receptor	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0623	0.0623
Brugia malayi	sulfakinin receptor protein	0.002	0.0131	0.0131
Echinococcus granulosus	neuropeptide s receptor	0.002	0.0131	0.0407
Trichomonas vaginalis	esterase, putative	0.0035	0.0549	0.1475
Echinococcus multilocularis	serotonin receptor	0.002	0.0131	0.0407
Schistosoma mansoni	neuropeptide receptor	0.002	0.0131	0.0407
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.3224	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0549	0.0808
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0131	0.0407
Schistosoma mansoni	growth hormone secretagogue receptor	0.002	0.0131	0.0407
Schistosoma mansoni	hypothetical protein	0.0033	0.0497	0.1541
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1151	0.3392
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0131	0.0131
Schistosoma mansoni	hypothetical protein	0.002	0.0131	0.0407
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.3224	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.0549
Echinococcus granulosus	neuropeptide receptor A26	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0549	0.1475
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.3224	0.3224
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0131	0.0407
Brugia malayi	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0131	0.0131
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.002	0.0131	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Schistosoma mansoni	ap endonuclease	0.0018	0.0086	0.0268
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0131	0.0407
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.0549
Schistosoma mansoni	neuropeptide receptor	0.002	0.0131	0.0407
Echinococcus granulosus	tachykinin peptides receptor 99D	0.002	0.0131	0.0407
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.002	0.0131	0.0407
Giardia lamblia	Glycogen phosphorylase	0.013	0.3224	1
Loa Loa (eye worm)	hypothetical protein	0.0372	1	1
Brugia malayi	G-protein coupled receptor	0.002	0.0131	0.0131
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0131	0.0407
Brugia malayi	beta-lactamase	0.0035	0.0549	0.0549
Brugia malayi	Dopamine receptor	0.002	0.0131	0.0131
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0131	0.0407
Schistosoma mansoni	opsin-like receptor	0.002	0.0131	0.0407
Brugia malayi	ORL1-like opioid receptor	0.002	0.0131	0.0131
Echinococcus granulosus	g-protein coupled receptor	0.002	0.0131	0.0407
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.002	0.0131	0.0131
Schistosoma mansoni	glycogen phosphorylase	0.013	0.3224	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0549	0.0467
Echinococcus granulosus	sex peptide receptor	0.002	0.0131	0.0407
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0549	0.0549
Toxoplasma gondii	ABC1 family protein	0.0035	0.0549	1
Brugia malayi	putative neuropeptide receptor NPR1	0.002	0.0131	0.0131
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0131	0.0407
Schistosoma mansoni	neuropeptide f receptor 76f	0.002	0.0131	0.0407
Brugia malayi	AKH receptor	0.002	0.0131	0.0131
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.3224	0.5
Schistosoma mansoni	amine GPCR	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Schistosoma mansoni	adenoreceptor	0.002	0.0131	0.0407
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0549	0.1475
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Echinococcus granulosus	neuropeptide receptor	0.002	0.0131	0.0407
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0549	0.0808
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0549	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.002	0.0131	0.0407
Brugia malayi	neuropeptide F receptor	0.002	0.0131	0.0131
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0131	0.0407
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.002	0.0131	0.0131

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.038 uM	Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme coupled assay	ChEMBL.	17095214
IC50 (binding)	= 0.038 uM	Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme coupled assay	ChEMBL.	17095214
IC50 (functional)	= 0.83 uM	Inhibition of glucose output in glucagon challenged primary rat hepatocytes	ChEMBL.	17095214
PPB (ADMET)	= 0.23 %	Plasma protein binding	ChEMBL.	17095214
Solubility	= 1.2 uM	Solubility in water	ChEMBL.	17095214

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL233657
PubChem: 10096162

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 439141