Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Arrow homolog | 0.0026 | 0.1882 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0016 | 0.0631 | 0.2801 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0631 | 0.0631 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0016 | 0.0631 | 0.2801 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0029 | 0.2253 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0016 | 0.0631 | 0.0631 |
Schistosoma mansoni | egf-like domain protein | 0.0026 | 0.1882 | 0.1335 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0016 | 0.0631 | 0.2801 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2253 | 0.2253 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0016 | 0.0631 | 0.3354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0016 | 0.0631 | 0.0631 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0029 | 0.2253 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0016 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0016 | 0.0631 | 0.0631 |
Echinococcus multilocularis | laminin | 0.0029 | 0.2253 | 0.1731 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0016 | 0.0631 | 0.0631 |
Brugia malayi | steroid hormone receptor | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0016 | 0.0631 | 0.2801 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0016 | 0.0631 | 0.0631 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0091 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0016 | 0.0631 | 0.2801 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0029 | 0.2253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3223 | 0.3223 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.9535 | 0.9535 |
Echinococcus multilocularis | fibrillin 1 | 0.0029 | 0.2253 | 0.1731 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0029 | 0.2253 | 0.2253 |
Echinococcus granulosus | laminin | 0.0029 | 0.2253 | 0.1731 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | ecdysteroid receptor | 0.0016 | 0.0631 | 0.2801 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0026 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0631 | 0.0631 |
Brugia malayi | nuclear receptor NHR-88 | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 0.0631 | 0.2801 |
Loa Loa (eye worm) | AStacin protease | 0.0057 | 0.5714 | 0.5714 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0016 | 0.0631 | 0.3354 |
Brugia malayi | Fibulin-1 precursor | 0.0029 | 0.2253 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0016 | 0.0631 | 0.2801 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1882 | 0.1882 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 0.0631 | 0.2801 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0016 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0016 | 0.0631 | 0.0631 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0091 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | nuclear hormone receptor | 0.0016 | 0.0631 | 0.2801 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0016 | 0.0631 | 0.3354 |
Onchocerca volvulus | 0.0016 | 0.0631 | 0.3354 | |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0016 | 0.0631 | 0.2801 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0026 | 0.1882 | 0.8351 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 202 nM | Inhibition of human ERbeta by radioligand binding assay | ChEMBL. | 17188490 |
IC50 (binding) | = 202 nM | Inhibition of human ERbeta by radioligand binding assay | ChEMBL. | 17188490 |
IC50 (binding) | = 1905 nM | Inhibition of human ERalpha by radioligand binding assay | ChEMBL. | 17188490 |
IC50 (binding) | = 1905 nM | Inhibition of human ERalpha by radioligand binding assay | ChEMBL. | 17188490 |
Ratio IC50 (binding) | = 9 | Selectivity for human ER beta over human ER alpha | ChEMBL. | 17188490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.