Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon receptor | 477 aa | 457 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0049 | 0.0093 | 0.0398 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1957 | 0.8416 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0433 | 0.0433 |
Onchocerca volvulus | Arrow homolog | 0.0112 | 0.1957 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0125 | 0.2325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.2325 | 0.2325 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1957 | 0.1957 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0049 | 0.0093 | 0.0398 |
Onchocerca volvulus | 0.0049 | 0.0093 | 0.0473 | |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.9539 | 0.9539 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.3285 | 0.3285 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0387 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0433 | 0.1864 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0125 | 0.2325 | 0.5 |
Loa Loa (eye worm) | DPY-31 protein | 0.0049 | 0.0093 | 0.0093 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0433 | 0.1864 |
Brugia malayi | astacin protease protein 30 | 0.0049 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0049 | 0.0093 | 0.0093 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0387 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0125 | 0.2325 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0433 | 0.0433 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0049 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1957 | 0.1957 |
Brugia malayi | Fibulin-1 precursor | 0.0125 | 0.2325 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0125 | 0.2325 | 0.2325 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0049 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | AStacin protease | 0.0242 | 0.5754 | 0.5754 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1957 | 0.1957 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 62 nM | Displacement of [125]glucagon from human glucagon receptor expressed in CHO cells | ChEMBL. | 17126016 |
IC50 (binding) | = 62 nM | Displacement of [125]glucagon from human glucagon receptor expressed in CHO cells | ChEMBL. | 17126016 |
IC50 (functional) | = 3434 nM | Antagonist activity at human glucagon receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation | ChEMBL. | 17126016 |
IC50 (functional) | = 3434 nM | Antagonist activity at human glucagon receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation | ChEMBL. | 17126016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.