Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.011 | 0.2322 | 0.213 |
Brugia malayi | Peptidase family M1 containing protein | 0.0039 | 0.0245 | 0.0002 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1125 | 0.4237 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Onchocerca volvulus | 0.011 | 0.2322 | 0.2322 | |
Brugia malayi | Peptidase family M1 containing protein | 0.011 | 0.2322 | 0.213 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0039 | 0.0245 | 0.5 |
Toxoplasma gondii | aminopeptidase N protein | 0.0039 | 0.0245 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.011 | 0.2322 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.6797 | 0.7659 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0245 | 0.0276 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0039 | 0.0245 | 0.5 |
Brugia malayi | TATA binding protein associated factor | 0.0039 | 0.0245 | 0.0002 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.1125 | 0.1267 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0245 | 0.0276 |
Trypanosoma cruzi | aminopeptidase, putative | 0.011 | 0.2322 | 1 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0039 | 0.0245 | 0.0276 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.011 | 0.2322 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.1125 | 0.0904 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1125 | 0.0902 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0245 | 0.0276 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0071 | 0.1195 | 0.0975 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0039 | 0.0245 | 0.0276 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0039 | 0.0245 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.011 | 0.2322 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.011 | 0.2322 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1125 | 0.0902 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.011 | 0.2322 | 1 |
Onchocerca volvulus | 0.0039 | 0.0245 | 0.0245 | |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0071 | 0.1195 | 0.4578 |
Echinococcus multilocularis | aminopeptidase N | 0.0373 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1125 | 0.4242 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.011 | 0.2322 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1125 | 0.0902 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.011 | 0.2322 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.011 | 0.2322 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0328 | 0.0411 |
Loa Loa (eye worm) | aminopeptidase N | 0.011 | 0.2322 | 0.2616 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0328 | 0.0328 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.011 | 0.2322 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0243 | 0.0274 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0245 | 0.0002 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1125 | 0.4242 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0039 | 0.0245 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.011 | 0.2322 | 0.2129 |
Echinococcus granulosus | aminopeptidase N | 0.0373 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.8874 | 1 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0039 | 0.0245 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.011 | 0.2322 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.011 | 0.2322 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0328 | 0.0411 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.011 | 0.2322 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0071 | 0.1195 | 0.4578 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0039 | 0.0245 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1195 | 0.1347 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0302 | 0.7923 | 0.8929 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1125 | 0.0902 |
Onchocerca volvulus | 0.0373 | 1 | 1 | |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.011 | 0.2322 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1195 | 0.1347 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1125 | 0.4237 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0039 | 0.0245 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0243 | 0.0243 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2322 | 0.2129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 18 % | Inhibition of human telomerase at 2 uM after 2 hrs by TRAP assay | ChEMBL. | 17317176 |
Inhibition (binding) | = 49 % | Inhibition of human telomerase at 5 uM after 2 hrs by TRAP assay | ChEMBL. | 17317176 |
Inhibition (binding) | = 55 % | Inhibition of human telomerase at 10 uM after 2 hrs by TRAP assay | ChEMBL. | 17317176 |
Inhibition (binding) | = 59 % | Inhibition of human telomerase at 20 uM after 2 hrs by TRAP assay | ChEMBL. | 17317176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.