Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin b | 0.0158 | 0.6076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0124 | 0.3698 | 0.5599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Echinococcus granulosus | cathepsin b | 0.0158 | 0.6076 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.0099 | 0.1917 | 0.1917 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0124 | 0.3698 | 0.6086 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0081 | 0.0672 | 0.1107 |
Onchocerca volvulus | Cathepsin F homolog | 0.0124 | 0.3698 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0158 | 0.6076 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.3698 | 0.6086 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0124 | 0.3698 | 0.6086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0124 | 0.3698 | 0.3698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0124 | 0.3698 | 0.6086 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.0099 | 0.1917 | 0.1917 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Onchocerca volvulus | 0.0124 | 0.3698 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0124 | 0.3698 | 0.6086 |
Loa Loa (eye worm) | fibroinase | 0.0124 | 0.3698 | 0.5599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Loa Loa (eye worm) | ctsf protein | 0.0124 | 0.3698 | 0.5599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0158 | 0.6076 | 0.6076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Echinococcus multilocularis | cathepsin b | 0.0158 | 0.6076 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Onchocerca volvulus | 0.0124 | 0.3698 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.3698 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0124 | 0.3698 | 0.3698 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0158 | 0.6076 | 0.6076 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0124 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.0672 | 0.1107 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.0672 | 0.133 |
Onchocerca volvulus | Cathepsin L homolog | 0.0124 | 0.3698 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0081 | 0.0672 | 0.1107 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0081 | 0.0672 | 0.1818 |
Entamoeba histolytica | cysteine protease, putative | 0.0124 | 0.3698 | 1 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.3698 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0124 | 0.3698 | 0.6086 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0158 | 0.6076 | 0.6076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0124 | 0.3698 | 0.6086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0124 | 0.3698 | 0.6086 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.0672 | 0.1107 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.3698 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0124 | 0.3698 | 0.3698 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0124 | 0.3698 | 0.5599 |
Plasmodium vivax | vivapain-2 | 0.0124 | 0.3698 | 0.3698 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.3698 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.3698 | 0.6086 |
Toxoplasma gondii | cathepsin CPL | 0.0124 | 0.3698 | 0.2204 |
Leishmania major | cysteine peptidase A (CPA) | 0.0124 | 0.3698 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0124 | 0.3698 | 0.3698 |
Onchocerca volvulus | 0.0124 | 0.3698 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0124 | 0.3698 | 0.6086 |
Onchocerca volvulus | Cathepsin L homolog | 0.0124 | 0.3698 | 1 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.3698 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0144 | 0.5057 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0081 | 0.0672 | 0.0672 |
Onchocerca volvulus | 0.0124 | 0.3698 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.3698 | 0.6086 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.3698 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3698 | 0.5599 |
Onchocerca volvulus | 0.0124 | 0.3698 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0124 | 0.3698 | 0.6086 |
Echinococcus granulosus | cathepsin b | 0.0158 | 0.6076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0124 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0215 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0124 | 0.3698 | 0.6086 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0124 | 0.3698 | 0.6086 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.3698 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.3698 | 0.6086 |
Onchocerca volvulus | 0.0124 | 0.3698 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.3698 | 0.6086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.3698 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0124 | 0.3698 | 0.3698 |
Toxoplasma gondii | cathepsin CPC1 | 0.0215 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.3698 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0215 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0215 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0158 | 0.6076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.0672 | 0.133 |
Brugia malayi | cathepsin L-like precursor | 0.0081 | 0.0672 | 0.1107 |
Loa Loa (eye worm) | cysteine protease | 0.0124 | 0.3698 | 0.5599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Onchocerca volvulus | 0.0124 | 0.3698 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0124 | 0.3698 | 0.6086 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0124 | 0.3698 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Echinococcus granulosus | cathepsin l1 | 0.0081 | 0.0672 | 0.1107 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.6076 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0124 | 0.3698 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.3698 | 0.7312 |
Echinococcus granulosus | cathepsin l1 | 0.0124 | 0.3698 | 0.6086 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0215 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0158 | 0.6076 | 0.6076 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0124 | 0.3698 | 0.3698 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0215 | 1 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0215 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.125 ug ml-1 | Antibacterial activity against Staphylococcus aureus UC 9218 | ChEMBL. | 17400450 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Staphylococcus aureus UC 9218 in presence of 10% human serum | ChEMBL. | 17400450 |
Ratio (functional) | = 32 % | Ratio of MIC of Staphylococcus aureus UC 9218 in presence of 10% serum to MIC of Staphylococcus aureus UC 9218 in absence of serum | ChEMBL. | 17400450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.