Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.301 | 0.3084 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0.301 | 0.2434 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.301 | 0.3084 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0.301 | 0.2434 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.5304 | 0.5392 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.301 | 0.2434 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.301 | 0.3084 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.7241 | 0.7241 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.5304 | 0.3282 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.5304 | 0.3282 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.6119 | 0.8166 |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.301 | 0.3084 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.301 | 0.3084 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0.301 | 0.2434 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.301 | 0.301 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.7241 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0032 | 0.301 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0.301 | 0.2434 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.301 | 0.3084 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.301 | 0.3084 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.301 | 0.3084 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.301 | 0.3084 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.301 | 0.3084 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.301 | 0.301 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.8878 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.301 | 0.301 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.301 | 0.301 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.301 | 0.301 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.301 | 0.2434 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.301 | 0.301 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0.301 | 0.2434 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.301 | 0.301 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.301 | 0.3084 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.301 | 0.3084 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.301 | 0.301 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.301 | 0.3084 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0032 | 0.301 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.301 | 0.3084 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.301 | 0.3084 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.301 | 0.301 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0.301 | 0.2434 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.301 | 0.301 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.301 | 0.3084 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.301 | 0.301 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0.301 | 0.2434 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0.301 | 0.2434 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0032 | 0.301 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.301 | 0.3084 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.301 | 0.2434 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0032 | 0.301 | 0.3084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.301 | 0.301 |
Onchocerca volvulus | 0.0032 | 0.301 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.301 | 0.3084 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.301 | 0.301 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0.301 | 0.2434 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.301 | 0.301 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.301 | 0.301 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.301 | 0.301 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0032 | 0.301 | 0.3084 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0.301 | 0.2434 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 360 nM | Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | ChEMBL. | 17590335 |
IC50 (binding) | = 360 nM | Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | ChEMBL. | 17590335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.