Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0308 | 1 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0308 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0308 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0308 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0308 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0308 | 1 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0308 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0308 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10.2 nM | Inhibition of calf PNP in presence of 1 mM phosphate | ChEMBL. | 17544667 |
IC50 (binding) | = 10.2 nM | Inhibition of calf PNP in presence of 1 mM phosphate | ChEMBL. | 17544667 |
IC50 (binding) | = 10.2 nM | Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic phosphate | ChEMBL. | 20189401 |
IC50 (binding) | = 20.4 nM | Inhibition of human PNP in presence of 1 mM phosphate | ChEMBL. | 17544667 |
IC50 (binding) | = 20.4 nM | Inhibition of human PNP in presence of 1 mM phosphate | ChEMBL. | 17544667 |
IC50 (binding) | = 20.4 nM | Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic phosphate | ChEMBL. | 20189401 |
Inhibition (binding) | Competitive inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis at 4.99 to 18.71 uM by Dixon plot analysis | ChEMBL. | 20189401 | |
Kd (binding) | = 1 10'-10M | Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry/ fluorimetric titration analysis | ChEMBL. | 23040896 |
Ki (binding) | = 1 nM | Inhibition of calf PNP in presence of 0.025 mM phosphate | ChEMBL. | 17544667 |
Ki (binding) | = 1 nM | Inhibition of human PNP in presence of 0.025 mM phosphate | ChEMBL. | 17544667 |
Ki (binding) | = 1 nM | Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.025 mM inorganic phosphate | ChEMBL. | 20189401 |
Ki (binding) | = 1 nM | Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.025 mM inorganic phosphate | ChEMBL. | 20189401 |
Ki (binding) | = 4.4 nM | Inhibition of calf PNP in presence of 1 mM phosphate | ChEMBL. | 17544667 |
Ki (binding) | = 4.4 nM | Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorganic phosphate | ChEMBL. | 20189401 |
Ki (binding) | = 6.9 nM | Inhibition of bovine PNP using 7-methylguanosine as substrate by spectrophotometric based coupled assay | ChEMBL. | 23040896 |
Ki (binding) | = 8.1 nM | Inhibition of human PNP in presence of 1 mM phosphate | ChEMBL. | 17544667 |
Ki (binding) | = 8.1 nM | Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorganic phosphate | ChEMBL. | 20189401 |
Ki app (binding) | = 1 nM | Inhibition of calf PNP in presence of 0.025 mM phosphate | ChEMBL. | 17544667 |
Ki app (binding) | = 1 nM | Inhibition of human PNP in presence of 0.025 mM phosphate | ChEMBL. | 17544667 |
Ki app (binding) | = 4.4 nM | Inhibition of calf PNP in presence of 1 mM phosphate | ChEMBL. | 17544667 |
Ki app (binding) | = 8.1 nM | Inhibition of human PNP in presence of 1 mM phosphate | ChEMBL. | 17544667 |
Kieq (binding) | = 0.085 nM | Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorganic phosphate | ChEMBL. | 20189401 |
Kieq (binding) | = 0.085 nM | Inhibition of bovine PNP using 7-methylguanosine as substrate by spectrophotometric based coupled assay | ChEMBL. | 23040896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.