Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | platelet-activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | g-protein coupled receptor | platelet-activating factor receptor | 342 aa | 302 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1279 | 0.2798 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0945 | 0.181 | 0.4828 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1279 | 0.2798 | 1 |
Plasmodium falciparum | plasmepsin II | 0.126 | 0.274 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.126 | 0.274 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0945 | 0.181 | 0.4828 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0645 | 0.0922 | 0.0922 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.3713 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 0.1875 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0945 | 0.181 | 0.4828 |
Plasmodium falciparum | plasmepsin I | 0.126 | 0.274 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0645 | 0.0922 | 0.0922 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1279 | 0.2798 | 1 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0645 | 0.0922 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 0.1875 | 0.5172 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.126 | 0.274 | 0.274 |
Plasmodium falciparum | plasmepsin VI | 0.126 | 0.274 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1279 | 0.2798 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.1279 | 0.2798 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1279 | 0.2798 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1279 | 0.2798 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.1279 | 0.2798 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.126 | 0.274 | 0.9699 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1279 | 0.2798 | 0.2798 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.126 | 0.274 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0645 | 0.0922 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 0.1875 | 0.5172 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0945 | 0.181 | 0.4828 |
Plasmodium falciparum | plasmepsin IV | 0.126 | 0.274 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.1279 | 0.2798 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.126 | 0.274 | 0.9692 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 0.1875 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.126 | 0.274 | 0.9699 |
Loa Loa (eye worm) | hypothetical protein | 0.0945 | 0.181 | 0.4828 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1279 | 0.2798 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0945 | 0.181 | 0.4828 |
Plasmodium vivax | plasmepsin IV, putative | 0.126 | 0.274 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0645 | 0.0922 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 0.1875 | 0.5172 |
Onchocerca volvulus | 0.0634 | 0.0888 | 0.5 | |
Mycobacterium ulcerans | zinc metalloprotease | 0.1279 | 0.2798 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 0.1875 | 0.5172 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.126 | 0.274 | 0.9692 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 420 nM | In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets. | ChEMBL. | 2016721 |
IC50 (binding) | = 420 nM | In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets. | ChEMBL. | 2016721 |
ID50 (functional) | = 0.2 mg kg-1 | In vivo inhibitory dose against PAF-induced bronchoconstriction in guinea pig upon intravenous administration after one-minute pre-treatment time. | ChEMBL. | 2016721 |
Inhibition (functional) | = 7 % | In vivo inhibition against PAF-induced bronchoconstriction in guinea pig at 1 mg/kg dose upon peroral administration after one-minute pre-treatment time. | ChEMBL. | 2016721 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.