Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | caspase 3, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cell death protein 3 precursor | caspase 3, apoptosis-related cysteine peptidase | 277 aa | 253 aa | 38.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.013 | 0.0154 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.013 | 0.0154 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.013 | 0.0154 | 0.0154 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.013 | 0.0154 | 0.0154 |
Echinococcus multilocularis | neuroligin | 0.013 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.013 | 0.0154 | 0.0154 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.013 | 0.0154 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.013 | 0.0154 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0768 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0768 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.0154 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0768 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0768 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0768 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.013 | 0.0154 | 0.5 |
Schistosoma mansoni | gliotactin | 0.013 | 0.0154 | 0.0154 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.013 | 0.0154 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.013 | 0.0154 | 0.0154 |
Echinococcus multilocularis | acetylcholinesterase | 0.0768 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0768 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.013 | 0.0154 | 0.0154 |
Echinococcus granulosus | BC026374 protein S09 family | 0.013 | 0.0154 | 0.0154 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.013 | 0.0154 | 0.0154 |
Onchocerca volvulus | 0.013 | 0.0154 | 0.5 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.013 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.013 | 0.0154 | 0.0154 |
Echinococcus granulosus | neuroligin | 0.013 | 0.0154 | 0.0154 |
Echinococcus granulosus | acetylcholinesterase | 0.0768 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0768 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.013 | 0.0154 | 0.0154 |
Schistosoma mansoni | acetylcholinesterase | 0.013 | 0.0154 | 0.0154 |
Onchocerca volvulus | 0.013 | 0.0154 | 0.5 | |
Onchocerca volvulus | 0.013 | 0.0154 | 0.5 | |
Onchocerca volvulus | 0.013 | 0.0154 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0768 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.013 | 0.0154 | 0.0154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.