Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.4458 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.1722 | 0.3086 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.1722 | 0.3086 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.3541 | 0.7682 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.4458 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.1722 | 0.3086 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.3541 | 0.7682 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.3541 | 0.7682 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.1722 | 0.3086 | 0.3086 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.1722 | 0.3086 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.1722 | 0.3086 | 0.3086 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.4458 | 1 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.3541 | 0.7682 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.3541 | 0.7682 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.4458 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.1595 | 0.2767 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.4458 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.1722 | 0.3086 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.3541 | 0.7682 | 0.5 |
Brugia malayi | hypothetical protein | 0.1209 | 0.1791 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.0031 | 0.0031 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1722 | 0.3086 | 0.3086 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.3541 | 0.7682 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1209 | 0.1791 | 0.1791 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.3541 | 0.7682 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.1722 | 0.3086 | 0.3086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 562 infected orally dosed Swiss albino mouse after 7 days | ChEMBL. | 17980588 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 after 24 hrs by agar dilution method | ChEMBL. | 17980588 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae ATCC 6303 after 24 hrs by agar dilution method | ChEMBL. | 17980588 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 33 after 24 hrs by agar dilution method | ChEMBL. | 17980588 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 6A after 24 hrs by agar dilution method | ChEMBL. | 17980588 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by agar dilution method | ChEMBL. | 17980588 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by agar dilution method | ChEMBL. | 17980588 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 562 after 24 hrs by agar dilution method | ChEMBL. | 17980588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.