Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0196 | 0.2601 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0171 | 0.1868 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0196 | 0.2601 | 0.2601 |
Giardia lamblia | Cathepsin B precursor | 0.0171 | 0.1868 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0196 | 0.2601 | 0.2601 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0196 | 0.2601 | 0.2601 |
Onchocerca volvulus | Cathepsin L homolog | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0196 | 0.2601 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0196 | 0.2601 | 0.2601 |
Leishmania major | cathepsin L-like protease | 0.0196 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0196 | 0.2601 | 0.2601 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.0828 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.2601 | 0.1934 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0171 | 0.1868 | 0.1868 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0196 | 0.2601 | 0.2601 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0196 | 0.2601 | 0.1934 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0171 | 0.1868 | 0.1868 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0449 | 1 | 1 |
Onchocerca volvulus | 0.0196 | 0.2601 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0135 | 0.0828 | 0.0828 |
Echinococcus multilocularis | cysteine protease | 0.0196 | 0.2601 | 0.2601 |
Entamoeba histolytica | cysteine protease, putative | 0.0196 | 0.2601 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0196 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0449 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0196 | 0.2601 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0196 | 0.2601 | 0.2601 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0449 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Echinococcus granulosus | cathepsin b | 0.0449 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0196 | 0.2601 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0449 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0196 | 0.2601 | 0.1934 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.0828 | 0.0828 |
Onchocerca volvulus | 0.0196 | 0.2601 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0196 | 0.2601 | 0.2601 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0196 | 0.2601 | 0.2601 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0449 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0171 | 0.1868 | 0.718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0135 | 0.0828 | 0.0828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0196 | 0.2601 | 0.2601 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0135 | 0.0828 | 0.0828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Onchocerca volvulus | 0.0196 | 0.2601 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0135 | 0.0828 | 0.0828 |
Leishmania major | cathepsin L-like protease | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0196 | 0.2601 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0196 | 0.2601 | 0.2601 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0196 | 0.2601 | 1 |
Plasmodium vivax | vivapain-2 | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0196 | 0.2601 | 0.2601 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0196 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | cysteine protease | 0.0196 | 0.2601 | 0.1934 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0196 | 0.2601 | 0.2601 |
Giardia lamblia | Cathepsin B precursor | 0.0171 | 0.1868 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0449 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Leishmania major | cathepsin L-like protease | 0.0196 | 0.2601 | 1 |
Onchocerca volvulus | 0.0196 | 0.2601 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0135 | 0.0828 | 0.3182 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0196 | 0.2601 | 0.2601 |
Onchocerca volvulus | Cathepsin L homolog | 0.0196 | 0.2601 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0196 | 0.2601 | 0.1934 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0196 | 0.2601 | 0.2601 |
Leishmania major | cathepsin L-like protease | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0196 | 0.2601 | 0.2601 |
Brugia malayi | cathepsin L-like precursor | 0.0135 | 0.0828 | 0.0828 |
Toxoplasma gondii | cathepsin CPL | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0196 | 0.2601 | 0.2601 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.0828 | 0.0828 |
Leishmania major | cathepsin L-like protease | 0.0196 | 0.2601 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0196 | 0.2601 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0171 | 0.1868 | 0.1134 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0196 | 0.2601 | 0.2601 |
Leishmania major | cathepsin L-like protease | 0.0196 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0196 | 0.2601 | 0.2601 |
Onchocerca volvulus | 0.0196 | 0.2601 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0196 | 0.2601 | 0.2601 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Onchocerca volvulus | 0.0196 | 0.2601 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0196 | 0.2601 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0196 | 0.2601 | 0.1934 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0171 | 0.1868 | 0.718 |
Onchocerca volvulus | 0.0196 | 0.2601 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0196 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0196 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.0828 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0196 | 0.2601 | 0.2601 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 54.9 % | Antiproliferative activity against human SaOS2 cells assessed as cellular viability at 12.5 uM after 48 hrs by MTT assay | ChEMBL. | 17929792 |
Activity (functional) | = 54.9 % | Antiproliferative activity against human SaOS2 cells assessed as cellular viability at 12.5 uM after 48 hrs by MTT assay | ChEMBL. | 17929792 |
Activity (functional) | = 113.4 % | Antiproliferative activity against human SaOS2 cells assessed as cellular viability at 12.5 uM after 24 hrs by MTT assay | ChEMBL. | 17929792 |
Activity (functional) | = 113.4 % | Antiproliferative activity against human SaOS2 cells assessed as cellular viability at 12.5 uM after 24 hrs by MTT assay | ChEMBL. | 17929792 |
Inhibition (ADMET) | = 85 % | Inhibition of human osteoblast growth at 25 uM after 48 hrs by MTT assay | ChEMBL. | 17929792 |
Ki (binding) | = 24 uM | Inhibition of human recombinant Src | ChEMBL. | 17929792 |
Ki (binding) | = 24 uM | Inhibition of human recombinant Src | ChEMBL. | 17929792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.