Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.1475 | 0.7394 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1335 | 0.1805 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.241 | 0.3259 |
Echinococcus multilocularis | carbonic anhydrase | 0.0272 | 0.1204 | 0.1104 |
Loa Loa (eye worm) | matrixin family protein | 0.0922 | 0.4549 | 0.6152 |
Brugia malayi | Matrixin family protein | 0.0416 | 0.1944 | 0.2323 |
Onchocerca volvulus | Matrilysin homolog | 0.1392 | 0.6967 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.1204 | 0.2569 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0095 | 0.0294 | 0.0184 |
Echinococcus granulosus | carbonic anhydrase II | 0.0579 | 0.2783 | 0.2701 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0265 | 0.0358 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0579 | 0.2783 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0272 | 0.1204 | 0.1628 |
Echinococcus granulosus | Tolloid protein 1 | 0.0093 | 0.0284 | 0.0174 |
Echinococcus multilocularis | geminin | 0.0173 | 0.0694 | 0.0588 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0272 | 0.1204 | 0.1281 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1204 | 0.1628 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.1983 | 0.2682 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0579 | 0.2783 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0272 | 0.1204 | 0.1281 |
Schistosoma mansoni | hypothetical protein | 0.059 | 0.2838 | 0.6415 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.4361 | 0.5898 |
Loa Loa (eye worm) | AStacin protease | 0.0058 | 0.0105 | 0.0141 |
Schistosoma mansoni | carbonic anhydrase | 0.0272 | 0.1204 | 0.2569 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0093 | 0.0284 | 0.0174 |
Echinococcus granulosus | carbonic anhydrase | 0.0272 | 0.1204 | 0.1104 |
Brugia malayi | Matrixin family protein | 0.0416 | 0.1944 | 0.2323 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0095 | 0.0294 | 0.0428 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0579 | 0.2783 | 0.3506 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.1944 | 0.2629 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0922 | 0.4549 | 0.5708 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0272 | 0.1204 | 0.2569 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0126 | 0.0455 | 0.0347 |
Echinococcus multilocularis | carbonic anhydrase | 0.0272 | 0.1204 | 0.1104 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.027 | 0.1195 | 0.2547 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0579 | 0.2783 | 0.3506 |
Brugia malayi | Hemopexin family protein | 0.059 | 0.2838 | 0.3583 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0272 | 0.1204 | 0.1281 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1204 | 0.1628 |
Mycobacterium ulcerans | hydrolase | 0.0506 | 0.241 | 1 |
Brugia malayi | hypothetical protein | 0.0297 | 0.1335 | 0.1466 |
Leishmania major | carbonic anhydrase-like protein | 0.0579 | 0.2783 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.1475 | 0.7394 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.1944 | 0.2629 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0506 | 0.241 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0579 | 0.2783 | 0.3764 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0579 | 0.2783 | 0.6287 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1982 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0579 | 0.2783 | 0.6287 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0506 | 0.241 | 0.8415 |
Brugia malayi | Matrixin family protein | 0.0416 | 0.1944 | 0.2323 |
Echinococcus granulosus | adam 17 protease | 0.0222 | 0.0945 | 0.0842 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0272 | 0.1204 | 0.1281 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0272 | 0.1204 | 0.2569 |
Onchocerca volvulus | 0.059 | 0.2838 | 0.2669 | |
Echinococcus granulosus | geminin | 0.0173 | 0.0694 | 0.0588 |
Echinococcus multilocularis | carbonic anhydrase | 0.0272 | 0.1204 | 0.1104 |
Onchocerca volvulus | Matrilysin homolog | 0.0416 | 0.1944 | 0.1081 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0579 | 0.2783 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0272 | 0.1204 | 0.1281 |
Onchocerca volvulus | 0.0416 | 0.1944 | 0.1081 | |
Echinococcus granulosus | carbonic anhydrase | 0.0272 | 0.1204 | 0.1104 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0093 | 0.0284 | 0.0385 |
Brugia malayi | Matrixin family protein | 0.0416 | 0.1944 | 0.2323 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0093 | 0.0284 | 0.0405 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0579 | 0.2783 | 0.3764 |
Echinococcus multilocularis | adam 17 protease | 0.0202 | 0.0841 | 0.0737 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0506 | 0.241 | 0.298 |
Mycobacterium tuberculosis | Possible exported protein | 0.0591 | 0.2843 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0579 | 0.2783 | 0.2701 |
Plasmodium falciparum | carbonic anhydrase | 0.0272 | 0.1204 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0886 | 0.4361 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0272 | 0.1204 | 0.2569 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0202 | 0.0841 | 0.1716 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0126 | 0.0455 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1204 | 0.1628 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.0694 | 0.1369 |
Echinococcus granulosus | carbonic anhydrase | 0.0272 | 0.1204 | 0.1104 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0095 | 0.0294 | 0.0184 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0416 | 0.1944 | 0.2629 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.0694 | 0.1369 |
Toxoplasma gondii | hypothetical protein | 0.0272 | 0.1204 | 1 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 17870540 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.