TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 466.652 | Formula: C30H42O4
H donors: 2 H acceptors: 3 LogP: 7.14 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: C/C=C/CCC/C=C(/C=C\1/OC(=O)C(=C1)/C=C/[C@@H]1C(=C)CC[C@H]2[C@@]1(C)CC[C@H]([C@@]2(C)CO)O)\C
InChi: 1S/C30H42O4/c1-6-7-8-9-10-11-21(2)18-24-19-23(28(33)34-24)13-14-25-22(3)12-15-26-29(25,4)17-16-27(32)30(26,5)20-31/h6-7,11,13-14,18-19,25-27,31-32H,3,8-10,12,15-17,20H2,1-2,4-5H3/b7-6+,14-13+,21-11+,24-18+/t25-,26+,27-,29+,30+/m1/s1
InChiKey: YBQFFTJCQNERRI-VJRKNGHWSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0036	0.0949	0.1559
Schistosoma mansoni	neuropeptide f receptor 76f	0.0036	0.0949	0.1559
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0777	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0036	0.0949	0.1559
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0036	0.0949	1
Schistosoma mansoni	myosin xvIII	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0949	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0949	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0284	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0949	0.1559
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0949	1
Echinococcus granulosus	neuropeptide receptor A26	0.0036	0.0949	1
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0949	1
Echinococcus granulosus	G protein coupled receptor 139	0.0036	0.0949	1
Brugia malayi	Dopamine receptor	0.0036	0.0949	0.1089
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0777	0.8181
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0949	1
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0949	1
Brugia malayi	follicle stimulating hormone receptor	0.0036	0.0949	0.1089
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0777	0.8181
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0949	0.1559
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0284	0.2997
Brugia malayi	Pre-SET motif family protein	0.0032	0.0777	0.0891
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Brugia malayi	Dopamine receptor protein 2	0.0036	0.0949	0.1089
Trichomonas vaginalis	set domain proteins, putative	0.0251	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0284	1
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0036	0.0949	1
Echinococcus granulosus	serotonin receptor	0.0036	0.0949	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0036	0.0949	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0036	0.0949	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0036	0.0949	0.1089
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	sex peptide receptor	0.0036	0.0949	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0036	0.0949	1
Echinococcus multilocularis	sex peptide receptor	0.0036	0.0949	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Brugia malayi	Melatonin receptor type 1A	0.0036	0.0949	0.1089
Echinococcus multilocularis	neuropeptide s receptor	0.0036	0.0949	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0284	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0036	0.0949	1
Echinococcus granulosus	orexin receptor type 2	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0949	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0949	0.1559
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0284	0.2997
Onchocerca volvulus		0.0032	0.0777	0.0777
Brugia malayi	Dopamine receptor protein 1	0.0036	0.0949	0.1089
Brugia malayi	Serotonin receptor	0.0036	0.0949	0.1089
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0949	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0036	0.0949	0.1089
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0036	0.0949	0.1089
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0036	0.0949	0.1559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0949	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0949	1
Schistosoma mansoni	opsin-like receptor	0.0036	0.0949	0.1559
Onchocerca volvulus		0.0036	0.0949	0.0949
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0036	0.0949	0.1559
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	serotonin receptor	0.0036	0.0949	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0949	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0949	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0036	0.0949	0.1089
Schistosoma mansoni	adenoreceptor	0.0036	0.0949	0.1559
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0949	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0949	0.1089
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0158	0.6086	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0777	0.0891
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0949	1
Onchocerca volvulus		0.0036	0.0949	0.0949
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0284	0.3663
Onchocerca volvulus		0.0036	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0036	0.0949	1
Echinococcus granulosus	somatostatin receptor	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.6086	0.6981
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Onchocerca volvulus		0.0036	0.0949	0.0949
Echinococcus granulosus	hypothetical protein	0.0036	0.0949	1
Brugia malayi	MH2 domain containing protein	0.0142	0.5419	0.6215
Schistosoma mansoni	amine GPCR	0.0036	0.0949	0.1559
Schistosoma mansoni	growth hormone secretagogue receptor	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	allatostatin A receptor	0.0036	0.0949	1
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0949	1
Onchocerca volvulus		0.0036	0.0949	0.0949
Echinococcus multilocularis	serotonin receptor	0.0036	0.0949	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0284	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0949	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0949	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0036	0.0949	1
Onchocerca volvulus		0.0036	0.0949	0.0949
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0284	0.0467
Echinococcus multilocularis	neuropeptide receptor A26	0.0036	0.0949	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0949	1
Onchocerca volvulus		0.0036	0.0949	0.0949
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0949	1
Onchocerca volvulus		0.0036	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0949	1
Brugia malayi	neuropeptide F receptor	0.0036	0.0949	0.1089
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0777	0.1276
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0158	0.6086	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0036	0.0949	0.1089
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0036	0.0949	0.1089
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0777	0.1276
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0036	0.0949	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0036	0.0949	0.1559
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0949	0.1559
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0777	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Onchocerca volvulus		0.0036	0.0949	0.0949
Echinococcus granulosus	dro:myosuppressin receptor	0.0036	0.0949	1
Echinococcus multilocularis	g-protein coupled receptor	0.0036	0.0949	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0036	0.0949	0.1089
Brugia malayi	larval opioid receptor	0.0036	0.0949	0.1089
Toxoplasma gondii	exonuclease III APE	0.002	0.0284	0.3663
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0949	0.1559
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0036	0.0949	0.1559
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0949	1
Brugia malayi	G-protein coupled receptor	0.0036	0.0949	0.1089
Echinococcus granulosus	neuropeptide s receptor	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0949	0.1559
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0036	0.0949	0.0949
Brugia malayi	sulfakinin receptor protein	0.0036	0.0949	0.1089
Onchocerca volvulus		0.0036	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0036	0.0949	0.1089
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0949	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0036	0.0949	1
Schistosoma mansoni	opsin-like receptor	0.0036	0.0949	0.1559
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0949	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0036	0.0949	1
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0949	0.1559
Echinococcus multilocularis	somatostatin receptor	0.0036	0.0949	1
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0949	0.1559
Echinococcus granulosus	fmrfamide receptor	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0284	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0036	0.0949	0.1559
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0949	0.1089
Onchocerca volvulus		0.0036	0.0949	0.0949
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0949	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0036	0.0949	1
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0949	1
Echinococcus granulosus	g-protein coupled receptor	0.0036	0.0949	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0949	0.1559
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0949	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0949	0.1559
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0949	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.022	0.8719	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Onchocerca volvulus		0.0036	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0777	0.1276
Brugia malayi	G protein-coupled receptor	0.0036	0.0949	0.1089
Onchocerca volvulus		0.0036	0.0949	0.0949
Schistosoma mansoni	d-amino acid oxidase	0.0158	0.6086	1
Echinococcus multilocularis	orexin receptor type 2	0.0036	0.0949	1
Onchocerca volvulus		0.0036	0.0949	0.0949
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0036	0.0949	0.0949
Onchocerca volvulus		0.0036	0.0949	0.0949
Schistosoma mansoni	amine GPCR	0.0036	0.0949	0.1559
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0949	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0949	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0949	1
Onchocerca volvulus		0.0036	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0949	0.1559
Loa Loa (eye worm)	TYRA-2 protein	0.0036	0.0949	0.1089
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0284	1
Brugia malayi	RE15519p	0.0036	0.0949	0.1089
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0036	0.0949	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Echinococcus multilocularis	G protein coupled receptor 139	0.0036	0.0949	1
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0036	0.0949	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0949	0.1089
Brugia malayi	putative neuropeptide receptor	0.0036	0.0949	0.1089
Schistosoma mansoni	opsin-like receptor	0.0036	0.0949	0.1559
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0777	0.8181
Schistosoma mansoni	amine GPCR	0.0036	0.0949	0.1559
Loa Loa (eye worm)	MH2 domain-containing protein	0.0142	0.5419	0.6215
Schistosoma mansoni	hypothetical protein	0.0036	0.0949	0.1559
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0284	1
Brugia malayi	Pre-SET motif family protein	0.022	0.8719	1
Plasmodium vivax	SET domain protein, putative	0.0032	0.0777	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0949	1
Brugia malayi	Serotonin receptor	0.0036	0.0949	0.1089
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0949	1
Schistosoma mansoni	amine GPCR	0.0036	0.0949	0.1559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0949	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0036	0.0949	1
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0013	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Schistosoma mansoni	hypothetical protein	0.0036	0.0949	0.1559
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0949	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0142	0.5419	0.6215
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0284	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0036	0.0949	1
Echinococcus multilocularis	allatostatin A receptor	0.0036	0.0949	1
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0949	0.1559
Brugia malayi	G-protein coupled receptor	0.0036	0.0949	0.1089
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0949	0.1559
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0949	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0949	1
Brugia malayi	ORL1-like opioid receptor	0.0036	0.0949	0.1089
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0036	0.0949	1
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0145	0.5533	1
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0284	0.0326
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0949	1
Onchocerca volvulus		0.0036	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0036	0.0949	0.1089
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0284	1
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Brugia malayi	G protein-coupled receptor F59B2.13	0.0036	0.0949	0.1089
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0036	0.0949	0.1559
Brugia malayi	hypothetical protein	0.0036	0.0949	0.1089
Brugia malayi	neuropeptide F receptor	0.0036	0.0949	0.1089
Brugia malayi	GnHR receptor homolog	0.0036	0.0949	0.1089
Schistosoma mansoni	histamine h1 receptor	0.0036	0.0949	0.1559
Schistosoma mansoni	hypothetical protein	0.0036	0.0949	0.1559
Schistosoma mansoni	amine GPCR	0.0036	0.0949	0.1559
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0949	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0284	0.0514
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0949	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0728	0.7666
Brugia malayi	AKH receptor	0.0036	0.0949	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0949	0.1089
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0036	0.0949	0.1089
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0036	0.0949	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0284	0.0326
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0949	1
Schistosoma mansoni	ap endonuclease	0.002	0.0284	0.0467
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0949	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0949	0.1559
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0949	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0949	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0036	0.0949	0.1089
Schistosoma mansoni	ap endonuclease	0.002	0.0284	0.0467

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	0	Inhibition of alpha-glucosidase at 100 uM	ChEMBL.	17428667

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 451816