Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0226 | 0.0623 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0226 | 0.0623 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.1362 | 0.654 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2027 | 1 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0226 | 0.0623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0623 | 0.0621 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0226 | 0.0623 | 0.0949 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0226 | 0.0623 | 0.0621 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2027 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0226 | 0.0623 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0226 | 0.0623 | 0.0949 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2027 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.1362 | 0.654 | 0.6539 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0226 | 0.0623 | 0.0623 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0226 | 0.0623 | 0.0623 |
Toxoplasma gondii | hypothetical protein | 0.0226 | 0.0623 | 0.1397 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0961 | 0.4447 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1362 | 0.654 | 0.6539 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0226 | 0.0623 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0226 | 0.0623 | 0.0949 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0226 | 0.0623 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0163 | 0.0293 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0021 | 0.0018 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0226 | 0.0623 | 0.0949 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0226 | 0.0623 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0226 | 0.0623 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.1996 | 0.9841 | 0.9841 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.1362 | 0.654 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0226 | 0.0623 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0226 | 0.0623 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.1362 | 0.654 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.0623 | 0.0621 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0226 | 0.0623 | 0.0623 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.1362 | 0.654 | 0.654 |
Brugia malayi | hypothetical protein | 0.0734 | 0.3267 | 0.3266 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.0623 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2027 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0226 | 0.0623 | 0.0949 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.0623 | 0.0621 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0226 | 0.0623 | 0.0623 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0107 | 0.0002 | 0.0002 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0226 | 0.0623 | 0.0621 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.1996 | 0.9841 | 0.9841 |
Echinococcus granulosus | prolyl endopeptidase | 0.0226 | 0.0623 | 0.0621 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.1362 | 0.654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0734 | 0.3267 | 0.3266 |
Trypanosoma cruzi | oligopeptidase b | 0.0226 | 0.0623 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0623 | 0.0621 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 0.0623 | 0.0621 |
Loa Loa (eye worm) | hypothetical protein | 0.0628 | 0.2716 | 0.2714 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.1362 | 0.654 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0226 | 0.0623 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0226 | 0.0623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0236 | 0.0234 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.1996 | 0.9841 | 0.9841 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0226 | 0.0623 | 0.1397 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.0623 | 0.0621 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2027 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0226 | 0.0623 | 0.0949 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0226 | 0.0623 | 0.0621 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0226 | 0.0623 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0226 | 0.0623 | 0.1397 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0313 | 0.0311 |
Mycobacterium tuberculosis | Probable peptidase | 0.0226 | 0.0623 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0226 | 0.0623 | 0.0621 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.1362 | 0.654 | 0.6539 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0226 | 0.0623 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0226 | 0.0623 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.