Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4A, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor co repressor related ncor | 0.0845 | 0.9768 | 0.9768 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0837 | 0.9661 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0837 | 0.9661 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0837 | 0.9661 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0837 | 0.9661 | 0.9661 |
Brugia malayi | Histone deacetylase 1 | 0.0625 | 0.6833 | 0.3353 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0518 | 0.5406 | 0.5596 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0625 | 0.6833 | 0.3353 |
Echinococcus granulosus | histone deacetylase 7 | 0.0837 | 0.9661 | 0.9661 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0625 | 0.6833 | 0.3353 |
Loa Loa (eye worm) | hypothetical protein | 0.0625 | 0.6833 | 0.7073 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0837 | 0.9661 | 0.9661 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0625 | 0.6833 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0837 | 0.9661 | 1 |
Giardia lamblia | Histone deacetylase | 0.0625 | 0.6833 | 1 |
Leishmania major | histone deacetylase, putative | 0.0837 | 0.9661 | 1 |
Leishmania major | histone deacetylase, putative | 0.0837 | 0.9661 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0625 | 0.6833 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.0837 | 0.9661 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0625 | 0.6833 | 0.6833 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0838 | 0.0868 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0343 | 0.3082 | 0.3082 |
Entamoeba histolytica | histone deacetylase, putative | 0.0625 | 0.6833 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0837 | 0.9661 | 0.9661 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0863 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0518 | 0.5406 | 0.5596 |
Loa Loa (eye worm) | histone deacetylase | 0.0837 | 0.9661 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0625 | 0.6833 | 0.5701 |
Trypanosoma brucei | histone deacetylase 1 | 0.0625 | 0.6833 | 0.5701 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0625 | 0.6833 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0837 | 0.9661 | 0.9661 |
Schistosoma mansoni | histone deacetylase | 0.0625 | 0.6833 | 0.6833 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0343 | 0.3082 | 0.3082 |
Echinococcus granulosus | histone deacetylase 6 | 0.0837 | 0.9661 | 0.9661 |
Echinococcus granulosus | histone deacetylase 8 | 0.0343 | 0.3082 | 0.3082 |
Echinococcus granulosus | histone deacetylase 1 | 0.0625 | 0.6833 | 0.6833 |
Brugia malayi | Histone deacetylase family protein | 0.0837 | 0.9661 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0837 | 0.9661 | 0.9661 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0343 | 0.3082 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0625 | 0.6833 | 0.7073 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.5093 | 0.5272 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0625 | 0.6833 | 0.5701 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0625 | 0.6833 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0625 | 0.6833 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0837 | 0.9661 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0863 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0837 | 0.9661 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0837 | 0.9661 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0625 | 0.6833 | 0.7073 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0625 | 0.6833 | 0.7073 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0625 | 0.6833 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0625 | 0.6833 | 0.7073 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0625 | 0.6833 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0837 | 0.9661 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0625 | 0.6833 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0625 | 0.6833 | 0.6833 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0625 | 0.6833 | 0.3353 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.3082 | 0.319 |
Trypanosoma brucei | histone deacetylase 4 | 0.0837 | 0.9661 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0625 | 0.6833 | 0.6833 |
Echinococcus multilocularis | nuclear receptor co repressor related (ncor) | 0.0845 | 0.9768 | 0.9768 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0837 | 0.9661 | 0.9661 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0837 | 0.9661 | 0.9661 |
Plasmodium falciparum | histone deacetylase 2 | 0.0837 | 0.9661 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0625 | 0.6833 | 0.6833 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0837 | 0.9661 | 0.9661 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0625 | 0.6833 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 0.5432 | 0.5623 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0837 | 0.9661 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0837 | 0.9661 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0343 | 0.3082 | 0.3082 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0343 | 0.3082 | 0.319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 nM | Inhibition of human recombinant phosphodiesterase 4A | ChEMBL. | 12031318 |
IC50 (binding) | = 5 nM | Inhibition of human recombinant phosphodiesterase 4A | ChEMBL. | 12031318 |
IC50 (functional) | = 5.9 uM | Inhibition of LPS-stimulated TNF-alpha production in human whole blood | ChEMBL. | 12031318 |
IC50 (functional) | = 5.9 uM | Inhibition of LPS-stimulated TNF-alpha production in human whole blood | ChEMBL. | 12031318 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12031318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.