Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dipeptidyl peptidase IV | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 789 aa | 30.2 % | |
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 637 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | thyroid hormone receptor | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | nuclear hormone receptor | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | FTZ F1 alpha | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0418 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0418 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | nuclear hormone receptor | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0371 | 0.7849 | 0.7849 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | coup transcription factor | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | ecdysteroid receptor | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0371 | 0.7849 | 0.7849 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0371 | 0.7849 | 0.7849 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0371 | 0.7849 | 0.7849 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | nuclear receptor NHR-88 | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | steroid hormone receptor | 0.0371 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0371 | 0.7849 | 0.7849 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0371 | 0.7849 | 0.7849 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13.5 nmol/L | Inhibition of DPP4 in human plasma by fluorescence assay | ChEMBL. | 17317162 |
IC50 (binding) | = 13.5 nmol/L | Inhibition of DPP4 in human plasma by fluorescence assay | ChEMBL. | 17317162 |
IC50 (binding) | = 16.9 nmol/L | Inhibition of DPP4 in rat plasma by fluorescence assay | ChEMBL. | 17317162 |
IC50 (binding) | = 16.9 nmol/L | Inhibition of DPP4 in rat plasma by fluorescence assay | ChEMBL. | 17317162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.