Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.2161 | 0.6759 |
Entamoeba histolytica | chitinase, putative | 0.0076 | 0.1894 | 1 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0039 | 0.0801 | 0.2504 |
Toxoplasma gondii | hypothetical protein | 0.0121 | 0.3198 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0076 | 0.1894 | 0.5922 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0011 | 0.0001 | 0.0001 |
Leishmania major | basic transcription factor 3a, putative | 0.0039 | 0.0801 | 0.2236 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 0.0801 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0487 | 0.152 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0039 | 0.0801 | 1 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0039 | 0.0801 | 0.4229 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.3523 | 0.4933 |
Brugia malayi | Endochitinase | 0.0085 | 0.2161 | 0.3026 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.2161 | 0.6759 |
Toxoplasma gondii | NAC domain-containing protein | 0.0039 | 0.0801 | 0.116 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0801 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Echinococcus multilocularis | geminin | 0.0354 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Echinococcus granulosus | transcription factor btf3 | 0.0039 | 0.0801 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0487 | 0.0682 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0039 | 0.0039 |
Schistosoma mansoni | transcription factor btf3 | 0.0039 | 0.0801 | 0.0801 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 1 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0121 | 0.3198 | 0.3198 |
Onchocerca volvulus | Putative endochitinase | 0.0011 | 0.0001 | 0.0003 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0256 | 0.7142 | 1 |
Leishmania major | chitinase | 0.0076 | 0.1894 | 1 |
Onchocerca volvulus | 0.0121 | 0.3198 | 1 | |
Brugia malayi | hypothetical protein | 0.0028 | 0.0487 | 0.0682 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0039 | 0.0039 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0039 | 0.0801 | 0.2504 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0801 | 0.4229 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0065 | 0.1567 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0074 | 0.1834 | 0.2568 |
Echinococcus granulosus | Glycoside hydrolase chitinase domain containing protein 1 | 0.0011 | 0.0001 | 0.0001 |
Echinococcus multilocularis | transcription factor btf3 | 0.0039 | 0.0801 | 0.0801 |
Loa Loa (eye worm) | ICD-1 protein | 0.0039 | 0.0801 | 0.1122 |
Loa Loa (eye worm) | chitinase I | 0.0076 | 0.1894 | 0.2651 |
Mycobacterium tuberculosis | Possible chitinase | 0.0065 | 0.1567 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 18 protein | 0.0011 | 0.0001 | 0.0001 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0199 | 0.0278 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.3198 | 0.4477 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0801 | 1 |
Brugia malayi | endochitinase | 0.0076 | 0.1894 | 0.2651 |
Echinococcus multilocularis | Glycoside hydrolase, chitinase domain containing protein 1 | 0.0011 | 0.0001 | 0.0001 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0487 | 0.152 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0011 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.3523 | 0.4933 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.3198 | 0.4477 |
Schistosoma mansoni | hypothetical protein | 0.0121 | 0.3198 | 0.3198 |
Brugia malayi | Endochitinase | 0.0011 | 0.0001 | 0.0001 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.3523 | 0.4933 |
Plasmodium vivax | hypothetical protein, conserved | 0.0121 | 0.3198 | 1 |
Schistosoma mansoni | chitinase | 0.0011 | 0.0001 | 0.0001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0487 | 0.152 |
Plasmodium falciparum | conserved protein, unknown function | 0.0121 | 0.3198 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0801 | 1 |
Brugia malayi | endochitinase | 0.0085 | 0.2161 | 0.3026 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0121 | 0.3198 | 0.3198 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0121 | 0.3198 | 0.4477 |
Onchocerca volvulus | Putative chitinase | 0.0011 | 0.0001 | 0.0003 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0076 | 0.1894 | 0.2651 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Onchocerca volvulus | Putative endochitinase | 0.0076 | 0.1894 | 0.5922 |
Brugia malayi | beta-NAC-like protein | 0.0039 | 0.0801 | 0.1122 |
Brugia malayi | follicle stimulating hormone receptor | 0.0256 | 0.7142 | 1 |
Onchocerca volvulus | 0.0121 | 0.3198 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0304 | 0.0304 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0065 | 0.1567 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1567 | 0.2194 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 0.0801 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.2161 | 0.6759 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 10.6 % | Antihyperglycemic activity in streptozotocin induced diabetic model of Sprague-Dawley albino rat assessed as reduction in blood glucose by AUC method | ChEMBL. | 17095211 |
Activity (functional) | = 21.7 % | Antihyperglycemic activity in sucrose loaded model of Sprague-Dawley albino rat assessed as reduction in blood glucose by AUC method | ChEMBL. | 17095211 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.