Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0801 | 0.4229 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0487 | 0.152 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.3198 | 0.4477 |
Toxoplasma gondii | NAC domain-containing protein | 0.0039 | 0.0801 | 0.116 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.3523 | 0.4933 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.2161 | 0.6759 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1567 | 0.2194 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0011 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0256 | 0.7142 | 1 |
Schistosoma mansoni | transcription factor btf3 | 0.0039 | 0.0801 | 0.0801 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0801 | 1 |
Loa Loa (eye worm) | ICD-1 protein | 0.0039 | 0.0801 | 0.1122 |
Brugia malayi | endochitinase | 0.0085 | 0.2161 | 0.3026 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.3523 | 0.4933 |
Onchocerca volvulus | Putative chitinase | 0.0011 | 0.0001 | 0.0003 |
Mycobacterium tuberculosis | Possible chitinase | 0.0065 | 0.1567 | 0.5 |
Onchocerca volvulus | 0.0121 | 0.3198 | 1 | |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0121 | 0.3198 | 0.3198 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0039 | 0.0801 | 0.2504 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0801 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 18 protein | 0.0011 | 0.0001 | 0.0001 |
Echinococcus multilocularis | geminin | 0.0354 | 1 | 1 |
Echinococcus multilocularis | Glycoside hydrolase, chitinase domain containing protein 1 | 0.0011 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0039 | 0.0039 |
Echinococcus multilocularis | transcription factor btf3 | 0.0039 | 0.0801 | 0.0801 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0076 | 0.1894 | 0.2651 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.3523 | 0.4933 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0039 | 0.0801 | 0.2504 |
Toxoplasma gondii | hypothetical protein | 0.0121 | 0.3198 | 1 |
Leishmania major | chitinase | 0.0076 | 0.1894 | 1 |
Brugia malayi | Endochitinase | 0.0011 | 0.0001 | 0.0001 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0039 | 0.0801 | 0.4229 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.2161 | 0.6759 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.3198 | 0.4477 |
Onchocerca volvulus | 0.0121 | 0.3198 | 1 | |
Brugia malayi | hypothetical protein | 0.0028 | 0.0487 | 0.0682 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0487 | 0.152 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0304 | 0.0304 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.2161 | 0.6759 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 1 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0065 | 0.1567 | 1 |
Echinococcus granulosus | Glycoside hydrolase chitinase domain containing protein 1 | 0.0011 | 0.0001 | 0.0001 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0199 | 0.0278 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0121 | 0.3198 | 0.4477 |
Brugia malayi | endochitinase | 0.0076 | 0.1894 | 0.2651 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0065 | 0.1567 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0801 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Brugia malayi | beta-NAC-like protein | 0.0039 | 0.0801 | 0.1122 |
Onchocerca volvulus | Putative endochitinase | 0.0076 | 0.1894 | 0.5922 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Brugia malayi | follicle stimulating hormone receptor | 0.0256 | 0.7142 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0121 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | chitinase I | 0.0076 | 0.1894 | 0.2651 |
Onchocerca volvulus | Putative endochitinase | 0.0076 | 0.1894 | 0.5922 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0039 | 0.0801 | 1 |
Brugia malayi | Endochitinase | 0.0085 | 0.2161 | 0.3026 |
Onchocerca volvulus | Putative endochitinase | 0.0011 | 0.0001 | 0.0003 |
Leishmania major | basic transcription factor 3a, putative | 0.0039 | 0.0801 | 0.2236 |
Schistosoma mansoni | chitinase | 0.0011 | 0.0001 | 0.0001 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0011 | 0.0001 | 0.0001 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0121 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0074 | 0.1834 | 0.2568 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 0.0801 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0487 | 0.152 |
Echinococcus granulosus | transcription factor btf3 | 0.0039 | 0.0801 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0487 | 0.0682 |
Plasmodium falciparum | conserved protein, unknown function | 0.0121 | 0.3198 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0121 | 0.3198 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 0.0801 | 1 |
Entamoeba histolytica | chitinase, putative | 0.0076 | 0.1894 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 10.6 % | Antihyperglycemic activity in streptozotocin induced diabetic model of Sprague-Dawley albino rat assessed as reduction in blood glucose by AUC method | ChEMBL. | 17095211 |
Activity (functional) | = 21.7 % | Antihyperglycemic activity in sucrose loaded model of Sprague-Dawley albino rat assessed as reduction in blood glucose by AUC method | ChEMBL. | 17095211 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.