Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.0038 | 0.0756 | 0.0756 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0139 | 0.9783 | 0.9783 |
Mycobacterium ulcerans | hydrolase | 0.0047 | 0.1503 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0093 | 0.5612 | 0.5612 |
Brugia malayi | Hemopexin family protein | 0.0054 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | AStacin protease | 0.0058 | 0.2504 | 0.2504 |
Onchocerca volvulus | 0.0142 | 1 | 1 | |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0047 | 0.1503 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0092 | 0.5605 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0092 | 0.5605 | 0.5605 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0142 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.2187 | 0.2951 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.003 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0047 | 0.1503 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0756 | 0.0756 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0091 | 0.5465 | 0.971 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.5269 | 0.5269 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.0054 | 0.2187 | 0.1548 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0756 | 0.0756 |
Onchocerca volvulus | Matrilysin homolog | 0.0085 | 0.4927 | 0.4512 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0038 | 0.0756 | 0.0756 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0142 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.0756 | 0.0756 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0085 | 0.4927 | 0.4512 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0047 | 0.1503 | 0.1503 |
Trypanosoma brucei | lipase domain protein, putative | 0.0142 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.0756 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0702 | 0.0702 |
Echinococcus granulosus | Tolloid protein 1 | 0.0092 | 0.5605 | 0.5605 |
Loa Loa (eye worm) | matrixin family protein | 0.0085 | 0.4927 | 0.4927 |
Leishmania major | hypothetical protein, conserved | 0.0142 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.0756 | 0.0756 |
Loa Loa (eye worm) | lipase | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1503 | 0.1503 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0756 | 0.0756 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0092 | 0.5605 | 0.5605 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0139 | 0.9783 | 0.9783 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0142 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0093 | 0.5612 | 0.5612 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0142 | 1 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0142 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0142 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0142 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.3 uM | Cytotoxicity against human MDA-MB468 cells by XTT assay | ChEMBL. | 17368022 |
IC50 (functional) | = 0.3 uM | Cytotoxicity against human MDA-MB468 cells by XTT assay | ChEMBL. | 17368022 |
IC50 (functional) | = 1.7 uM | Cytotoxicity against human MCF7 cells by XTT assay | ChEMBL. | 17368022 |
IC50 (functional) | = 1.7 uM | Cytotoxicity against human MCF7 cells by XTT assay | ChEMBL. | 17368022 |
IC50 (functional) | = 3.9 uM | Cytotoxicity against human HCT116 cells by XTT assay | ChEMBL. | 17368022 |
IC50 (functional) | = 3.9 uM | Cytotoxicity against human HCT116 cells by XTT assay | ChEMBL. | 17368022 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17368022 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.