TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 441.604 | Formula: C30H35NO2
H donors: 2 H acceptors: 2 LogP: 8.14 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(c2c1cccc2)O)/C=C(/C=C\C=C(/C=C\C1=C(C)CCCC1(C)C)\C)\C
InChi: 1S/C30H35NO2/c1-21(15-16-26-23(3)12-9-19-30(26,4)5)10-8-11-22(2)20-29(33)31-27-17-18-28(32)25-14-7-6-13-24(25)27/h6-8,10-11,13-18,20,32H,9,12,19H2,1-5H3,(H,31,33)/b11-8+,16-15+,21-10+,22-20+
InChiKey: ABYFTOLNIBSHLL-HTCCTQIJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	integrin alpha-4	0.0382	0.1672	0.2493
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Giardia lamblia	Neurogenic locus notch-like protein	0.0076	0.0147	0.5
Echinococcus multilocularis	glycoprotein Antigen 5	0.0118	0.036	0.0428
Brugia malayi	excitatory GABA receptor EXP-1A	0.0065	0.0094	0.0071
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0065	0.0094	0.0084
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0204	0.0784	0.115
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0124	0.0101
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0147	0.0124
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Loa Loa (eye worm)	calcium channel	0.0093	0.0235	0.0213
Echinococcus multilocularis	integrin alpha ps	0.0085	0.0195	0.0232
Onchocerca volvulus		0.0621	0.2861	0.8245
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.074	0.3449	0.3434
Onchocerca volvulus		0.0071	0.0124	0.009
Echinococcus multilocularis	lysine specific demethylase 5A	0.0062	0.0078	0.0092
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Schistosoma mansoni	jumonji domain containing protein	0.0062	0.0078	0.0083
Brugia malayi	hypothetical protein	0.0356	0.1543	0.1524
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0146	0.0498	0.0719
Echinococcus granulosus	Mastin	0.0118	0.036	0.0402
Toxoplasma gondii	hypothetical protein	0.0076	0.0147	0.0055
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0078	0.0083
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0065	0.0094	0.0071
Echinococcus multilocularis	adam	0.0076	0.0147	0.0175
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0093	0.0235	0.0321
Schistosoma mansoni	serine-type protease inhibitor	0.0433	0.1924	0.2874
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0093	0.0235	0.0213
Schistosoma mansoni	hypothetical protein	0.0175	0.0641	0.0935
Brugia malayi	Trypsin family protein	0.0118	0.036	0.0338
Schistosoma mansoni	integrin alpha-ps	0.0178	0.0655	0.0956
Schistosoma mansoni	tyrosine kinase	0.0083	0.0184	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0641	0.062
Brugia malayi	CUB domain containing protein	0.006	0.0068	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0031	0.0008
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0065	0.0094	0.0111
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0065	0.0094	0.0071
Echinococcus granulosus	glycine receptor subunit beta	0.0065	0.0094	0.0084
Brugia malayi	jmjC domain containing protein	0.0062	0.0078	0.0055
Onchocerca volvulus		0.0076	0.0147	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0118	0.036	0.0338
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0031	0.0008
Brugia malayi	Trypsin family protein	0.074	0.3449	0.3434
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0065	0.0094	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Brugia malayi	Kringle domain containing protein	0.017	0.0615	0.0593
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0093	0.0235	0.0321
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0093	0.0235	0.028
Echinococcus multilocularis	integrin beta 2	0.1738	0.8411	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0065	0.0094	0.0071
Brugia malayi	Receptor family ligand binding region containing protein	0.0087	0.0202	0.0179
Echinococcus multilocularis	fibrillin 1	0.0076	0.0147	0.0175
Onchocerca volvulus		0.0175	0.0641	0.1632
Echinococcus multilocularis	kelch ECH associated protein 1	0.0091	0.0225	0.0268
Loa Loa (eye worm)	hypothetical protein	0.017	0.0615	0.0593
Echinococcus granulosus	glycine receptor subunit beta	0.0065	0.0094	0.0084
Onchocerca volvulus		0.074	0.3449	1
Schistosoma mansoni	tyrosine kinase	0.0079	0.0164	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0118	0.036	0.0402
Schistosoma mansoni	integrin alpha-ps	0.0154	0.0536	0.0776
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0065	0.0094	0.0111
Echinococcus granulosus	fibrillin 2	0.0076	0.0147	0.0148
Trichomonas vaginalis	hypothetical protein	0.0076	0.0147	0.5
Giardia lamblia	Tenascin-X	0.0076	0.0147	0.5
Brugia malayi	Trypsin family protein	0.0118	0.036	0.0338
Onchocerca volvulus		0.0071	0.0124	0.009
Brugia malayi	jmjC domain containing protein	0.0062	0.0078	0.0055
Loa Loa (eye worm)	ACC-1 protein	0.0065	0.0094	0.0071
Echinococcus granulosus	receptor type guanylyl cyclase	0.0087	0.0202	0.0213
Loa Loa (eye worm)	hypothetical protein	0.006	0.0068	0.0045
Schistosoma mansoni	nAChR subunit	0.0065	0.0094	0.0107
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0118	0.036	0.0509
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0075	0.0146	0.0173
Loa Loa (eye worm)	PAN domain-containing protein	0.0071	0.0124	0.0101
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0118	0.036	0.0338
Echinococcus multilocularis	integrin alpha ps	0.0239	0.096	0.1141
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0087	0.0202	0.0179
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0065	0.0094	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0147	0.05	0.0478
Brugia malayi	Muscle positioning protein 4	0.0175	0.0641	0.062
Loa Loa (eye worm)	hypothetical protein	0.0204	0.0784	0.0763
Echinococcus granulosus	transmembrane protease serine 3	0.0118	0.036	0.0402
Echinococcus granulosus	integrin alpha 3	0.0085	0.0195	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0118	0.036	0.0338
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0062	0.0078	0.0065
Brugia malayi	EGF-like domain containing protein	0.0076	0.0147	0.0124
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0093	0.0235	0.028
Toxoplasma gondii	PAN domain-containing protein	0.09	0.4248	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0093	0.0235	0.028
Plasmodium falciparum	cysteine repeat modular protein 1	0.017	0.0615	0.5
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0384	0.1682	0.1662
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0087	0.0202	0.024
Echinococcus multilocularis	kelch ECH associated protein 1	0.0091	0.0225	0.0268
Giardia lamblia	High cysteine protein	0.0076	0.0147	0.5
Loa Loa (eye worm)	PAN domain-containing protein	0.0071	0.0124	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0235	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.006	0.0068	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0147	0.05	0.0478
Schistosoma mansoni	nAChR subunit	0.0065	0.0094	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Echinococcus multilocularis	epidermal growth factor receptor	0.0152	0.0526	0.0626
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0065	0.0094	0.0084
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0118	0.036	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Onchocerca volvulus		0.0071	0.0124	0.009
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0118	0.036	0.0509
Schistosoma mansoni	nAChR subunit	0.0065	0.0094	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0536	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0658	0.0636
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0057	0.0053	0.5
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Schistosoma mansoni	nAChR subunit	0.0065	0.0094	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0147	0.0124
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0065	0.0094	0.0107
Onchocerca volvulus		0.0118	0.036	0.0793
Schistosoma mansoni	nAChR subunit	0.0065	0.0094	0.0107
Schistosoma mansoni	integrin beta subunit	0.1381	0.6639	1
Echinococcus multilocularis	enteropeptidase	0.0118	0.036	0.0428
Brugia malayi	Cation transporter family protein	0.0065	0.0094	0.0071
Toxoplasma gondii	kringle domain-containing protein	0.017	0.0615	0.119
Echinococcus granulosus	adam	0.0076	0.0147	0.0148
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0062	0.0078	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0641	0.062
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0065	0.0094	0.0111
Echinococcus multilocularis	tissue type plasminogen activator	0.017	0.0615	0.0731
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0118	0.036	0.0509
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0065	0.0094	0.0111
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0065	0.0094	0.0084
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0065	0.0094	0.0071
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0065	0.0094	0.0084
Echinococcus multilocularis	epidermal growth factor receptor	0.0083	0.0184	0.0219
Onchocerca volvulus		0.0118	0.036	0.0793
Onchocerca volvulus		0.0071	0.0124	0.009
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0078	0.0083
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0065	0.0094	0.0084
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0152	0.0526	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0118	0.036	0.0338
Echinococcus granulosus	geminin	0.0178	0.0655	0.0753
Brugia malayi	Trypsin family protein	0.0118	0.036	0.0338
Echinococcus multilocularis	integrin alpha 3	0.0085	0.0195	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0093	0.0235	0.0253
Loa Loa (eye worm)	integrin alpha pat-2	0.0178	0.0655	0.0634
Echinococcus multilocularis	fibrillin 2	0.0076	0.0147	0.0175
Loa Loa (eye worm)	PAN domain-containing protein	0.0071	0.0124	0.0101
Onchocerca volvulus		0.0071	0.0124	0.009
Onchocerca volvulus		0.0175	0.0641	0.1632
Echinococcus multilocularis	glycine receptor subunit beta	0.0065	0.0094	0.0111
Echinococcus multilocularis	Mastin	0.0118	0.036	0.0428
Echinococcus multilocularis	transmembrane protease serine 3	0.0118	0.036	0.0428
Brugia malayi	Trypsin-like protease protein 5	0.0118	0.036	0.0338
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Onchocerca volvulus		0.0175	0.0641	0.1632
Schistosoma mansoni	serine-type protease inhibitor	0.0433	0.1924	0.2874
Schistosoma mansoni	nAChR subunit	0.0065	0.0094	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0204	0.0784	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0124	0.0101
Echinococcus multilocularis	nAChR subunit	0.0065	0.0094	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0147	0.0124
Echinococcus multilocularis	glycine receptor subunit beta	0.0065	0.0094	0.0111
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0118	0.036	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0231	0.0209
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0065	0.0094	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0124	0.0101
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0065	0.0094	0.0071
Echinococcus granulosus	glycoprotein Antigen 5	0.0118	0.036	0.0402
Loa Loa (eye worm)	PAN domain-containing protein	0.0071	0.0124	0.0101
Echinococcus multilocularis	geminin	0.0178	0.0655	0.0778
Echinococcus multilocularis	integrin alpha ps	0.0178	0.0655	0.0779
Onchocerca volvulus		0.0071	0.0124	0.009
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0075	0.0146	0.0147
Onchocerca volvulus		0.0071	0.0124	0.009
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.074	0.3449	0.5179
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Schistosoma mansoni	tyrosine kinase	0.0152	0.0526	0.0761
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0065	0.0094	0.0111
Echinococcus granulosus	enteropeptidase	0.0118	0.036	0.0402
Giardia lamblia	Tenascin precursor	0.0076	0.0147	0.5
Giardia lamblia	Neurogenic locus Notch protein precursor	0.0076	0.0147	0.5
Schistosoma mansoni	hypothetical protein	0.0118	0.036	0.0509
Echinococcus granulosus	fibrillin 1	0.0076	0.0147	0.0148
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0147	0.05	0.0478
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0065	0.0094	0.0084
Loa Loa (eye worm)	hypothetical protein	0.074	0.3449	0.3434
Echinococcus granulosus	epidermal growth factor receptor	0.0152	0.0526	0.06
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0118	0.036	0.0338
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0078	0.0055
Brugia malayi	Cation transporter family protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	trypsin family protein	0.0118	0.036	0.0338
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0065	0.0094	0.0071
Onchocerca volvulus		0.0071	0.0124	0.009
Giardia lamblia	Tenascin-37	0.0076	0.0147	0.5
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0065	0.0094	0.0071
Echinococcus granulosus	kelch ECH associated protein 1	0.0091	0.0225	0.0241
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0087	0.0202	0.0179
Onchocerca volvulus		0.0204	0.0784	0.2056
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0083	0.0184	0.0192
Brugia malayi	Integrin alpha pat-2 precursor	0.0178	0.0655	0.0634
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0124	0.0101
Echinococcus multilocularis	protein jagged 2	0.0076	0.0147	0.0175
Schistosoma mansoni	integrin alpha	0.0178	0.0655	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	PAN domain-containing protein	0.0071	0.0124	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Echinococcus multilocularis	insulin receptor	0.0051	0.0023	0.0027
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0065	0.0094	0.0071
Schistosoma mansoni	tyrosine kinase	0.0079	0.0164	0.0214
Schistosoma mansoni	tyrosine kinase	0.0083	0.0184	0.0243
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0065	0.0094	0.0111
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0124	0.0101
Mycobacterium ulcerans	hypothetical protein	0.0118	0.036	1
Loa Loa (eye worm)	hypothetical protein	0.0118	0.036	0.0338
Brugia malayi	Furin-like cysteine rich region family protein	0.0152	0.0526	0.0505
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0031	0.0008
Brugia malayi	EGF-like domain containing protein	0.0076	0.0147	0.0124
Onchocerca volvulus		0.0175	0.0641	0.1632
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0065	0.0094	0.0071
Giardia lamblia	Tenascin-like	0.0076	0.0147	0.5
Giardia lamblia	High cysteine protein	0.0076	0.0147	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0065	0.0094	0.0071
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0204	0.0784	0.115
Brugia malayi	SEA domain containing protein	0.0175	0.0641	0.062
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Echinococcus granulosus	lysine specific demethylase 5A	0.0062	0.0078	0.0065
Onchocerca volvulus		0.017	0.0615	0.1553
Schistosoma mansoni	nAChR subunit	0.0065	0.0094	0.0107
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Onchocerca volvulus		0.0118	0.036	0.0793
Brugia malayi	Cation transporter family protein	0.0204	0.0784	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0076	0.0053
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0118	0.036	0.0509
Schistosoma mansoni	voltage-gated cation channel	0.0093	0.0235	0.0321
Onchocerca volvulus		0.0118	0.036	0.0793
Onchocerca volvulus		0.0071	0.0124	0.009
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0118	0.036	0.0428
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0065	0.0094	0.0071
Brugia malayi	hypothetical protein	0.0118	0.036	0.0338
Loa Loa (eye worm)	LGC-31 protein	0.0065	0.0094	0.0071
Leishmania major	hypothetical protein, conserved	0.017	0.0615	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0065	0.0094	0.0107
Giardia lamblia	hypothetical protein	0.0076	0.0147	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Onchocerca volvulus		0.0175	0.0641	0.1632
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0093	0.0235	0.0253
Brugia malayi	EGF-like domain containing protein	0.0076	0.0147	0.0124
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0118	0.036	0.0428
Schistosoma mansoni	hypothetical protein	0.0085	0.0195	0.026
Echinococcus granulosus	voltage dependent calcium channel	0.0093	0.0235	0.0253
Toxoplasma gondii	PAN domain-containing protein	0.09	0.4248	1
Echinococcus granulosus	epidermal growth factor receptor	0.0083	0.0184	0.0192
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0093	0.0235	0.028
Loa Loa (eye worm)	DOMON domain-containing protein	0.0175	0.0641	0.062
Echinococcus multilocularis	Kelch repeat type 1	0.0092	0.0227	0.0269
Onchocerca volvulus		0.0204	0.0784	0.2056
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0065	0.0094	0.0107
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Echinococcus granulosus	nAChR subunit	0.0065	0.0094	0.0084
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0065	0.0094	0.0071
Echinococcus granulosus	integrin beta 2	0.1738	0.8411	1
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0065	0.0094	0.0084
Echinococcus multilocularis	voltage dependent calcium channel	0.0093	0.0235	0.028
Trypanosoma cruzi	hypothetical protein, conserved	0.017	0.0615	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.08	0.3746	0.5628
Schistosoma mansoni	hypothetical protein	0.0178	0.0655	0.0955
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0065	0.0094	0.0071
Schistosoma mansoni	tyrosine kinase	0.0079	0.0164	0.0214
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0065	0.0094	0.0111
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0087	0.0202	0.0323
Echinococcus granulosus	tissue type plasminogen activator	0.017	0.0615	0.0706
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0031	0.0008
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0065	0.0094	0.0071
Schistosoma mansoni	protein kinase	0.0087	0.0202	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0124	0.0101
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Brugia malayi	Protein kinase domain containing protein	0.0174	0.0635	0.0613
Loa Loa (eye worm)	ACC-1 protein	0.0065	0.0094	0.0071
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0065	0.0094	0.0084
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0091	0.0225	0.0241
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0065	0.0094	0.0084
Loa Loa (eye worm)	TK/ROR protein kinase	0.0174	0.0635	0.0613
Schistosoma mansoni	hypothetical protein	0.017	0.0615	0.0895
Onchocerca volvulus		0.0204	0.0784	0.2056
Echinococcus granulosus	integrin alpha ps	0.0085	0.0195	0.0205
Onchocerca volvulus		0.0071	0.0124	0.009
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.017	0.0615	0.5
Schistosoma mansoni	hypothetical protein	0.0178	0.0655	0.0955
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0093	0.0235	0.0253
Echinococcus multilocularis	voltage dependent calcium channel	0.0093	0.0235	0.028
Brugia malayi	Kelch motif family protein	0.0384	0.1682	0.1662
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0065	0.0094	0.0111
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Loa Loa (eye worm)	integrin beta-2	0.2057	1	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0065	0.0094	0.0071
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0091	0.0225	0.0241
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0065	0.0094	0.0084
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0051	0.0023	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0356	0.1543	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0094	0.0071
Brugia malayi	EGF-like domain containing protein	0.0076	0.0147	0.0124
Onchocerca volvulus		0.0071	0.0124	0.009
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0065	0.0094	0.0111
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0065	0.0094	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0124	0.0101
Schistosoma mansoni	hypothetical protein	0.0092	0.0227	0.0308
Schistosoma mansoni	cercarial elastase (S01 family)	0.0118	0.036	0.0509
Brugia malayi	PAN domain containing protein	0.0071	0.0124	0.0101
Schistosoma mansoni	hypothetical protein	0.0118	0.036	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0147	0.0124
Onchocerca volvulus		0.0118	0.036	0.0793
Trichomonas vaginalis	teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative	0.0076	0.0147	0.5
Echinococcus granulosus	integrin alpha ps	0.0239	0.096	0.1117

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 510813

Bibliographic References

No literature references available for this target.

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Detailed information for compound 455905