Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.0045 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0028 | 0.0045 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.0045 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.0045 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0028 | 0.0045 | 0.5 |
Giardia lamblia | ABC transporter, putative | 0.0028 | 0.0045 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1474 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0045 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1474 | 1 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0338 | 0.2179 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.0045 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0045 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.0045 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1474 | 1 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0028 | 0.0045 | 0.5 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0028 | 0.0045 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0028 | 0.0045 | 0.5 |
Brugia malayi | multidrug resistance related protein 1 | 0.0028 | 0.0045 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0045 | 0.0044 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1474 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.0045 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0028 | 0.0045 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0028 | 0.0045 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0045 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0044 | 0.0042 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0028 | 0.0045 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0338 | 0.2179 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0028 | 0.0045 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.0045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0045 | 0.0044 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0028 | 0.0045 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0028 | 0.0045 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0045 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0028 | 0.0045 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0028 | 0.0045 | 0.0044 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.0045 | 0.5 |
Leishmania major | pentamidine resistance protein 1 | 0.0028 | 0.0045 | 0.5 |
Trypanosoma brucei | multidrug resistance protein E | 0.0028 | 0.0045 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0028 | 0.0045 | 1 |
Leishmania major | p-glycoprotein e | 0.0028 | 0.0045 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.0028 | 0.0045 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.0028 | 0.0045 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0028 | 0.0045 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0045 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0028 | 0.0045 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.3 uM | Inhibition of human 11beta-HSD1 expressed in HEK293 cells after 2 hrs by scintillation proximity assay | ChEMBL. | 17350260 |
IC50 (binding) | = 7.3 uM | Inhibition of human 11beta-HSD1 expressed in HEK293 cells after 2 hrs by scintillation proximity assay | ChEMBL. | 17350260 |
Inhibition (binding) | Inhibition of human 11beta-HSD2 at 10 uM by scintillation proximity assay | ChEMBL. | 17350260 | |
Inhibition (binding) | 0 | Inhibition of human 11beta-HSD2 at 10 uM by scintillation proximity assay | ChEMBL. | 17350260 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.