Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0028 | 0.0047 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0028 | 0.0047 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0045 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0047 | 0.0045 |
Brugia malayi | multidrug resistance related protein 1 | 0.0028 | 0.0047 | 0.5 |
Trypanosoma brucei | p-glycoprotein | 0.0028 | 0.0047 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.0047 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0028 | 0.0047 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.0047 | 1 |
Leishmania major | pentamidine resistance protein 1 | 0.0028 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0047 | 0.0045 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0047 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0028 | 0.0047 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0028 | 0.0047 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.0047 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.0047 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0047 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.0028 | 0.0047 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0028 | 0.0047 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0028 | 0.0047 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0028 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0028 | 0.0047 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0028 | 0.0047 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1408 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 1 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0028 | 0.0047 | 0.5 |
Leishmania major | p-glycoprotein e | 0.0028 | 0.0047 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0028 | 0.0047 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.0047 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1408 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0047 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0028 | 0.0047 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0028 | 0.0047 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0028 | 0.0047 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0028 | 0.0047 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.0047 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0047 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0028 | 0.0047 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0028 | 0.0047 | 0.0045 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.0047 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Neuroprotective activity against paclitaxel-induced toxicity in mouse P19 derived neurons assessed as cell viability at 1 nM after 18 hrs by phase contrast microscope | ChEMBL. | 17442565 |
Activity (functional) | 0 | Neuroprotective activity against vinblastine-induced toxicity in mouse P19 derived neurons assessed as cell viability at 1 nM after 18 hrs by phase contrast microscope | ChEMBL. | 17442565 |
Activity (functional) | = 108 % | Cell viability of mouse P19 derived neurons at 1 nM by XTT reduction assay relative to control | ChEMBL. | 17442565 |
Activity (functional) | = 120 % | Neuroprotective activity against paclitaxel-induced toxicity in mouse P19 derived neurons assessed as cell viability at 1 nM | ChEMBL. | 17442565 |
IC50 (ADMET) | > 10 uM | Neurotoxicity against mouse P19 derived neurons after 18 hrs | ChEMBL. | 17442565 |
IC50 (functional) | > 10 uM | Cytotoxicity against mouse P19 cells after 18 hrs | ChEMBL. | 17442565 |
IC50 (functional) | > 10 uM | Cytotoxicity against mouse P19 cells after 18 hrs | ChEMBL. | 17442565 |
Ratio (functional) | > 10000 | Therapeutic index, ratio of neurotoxic IC50 to neuroprotective activity for mouse P19 derived neurons | ChEMBL. | 17442565 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 17442565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.