Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma brucei | trans-sialidase, putative | 0.0117 | 0.0601 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0314 | 0.2051 | 0.5934 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1393 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1393 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma brucei | trans-sialidase, putative | 0.0117 | 0.0601 | 1 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0432 | 0.2925 | 0.2925 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0117 | 0.0601 | 1 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.0505 | 0.3456 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0117 | 0.0601 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0117 | 0.0601 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1393 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0117 | 0.0601 | 0.9998 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0117 | 0.0601 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0117 | 0.0601 | 0.9998 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1393 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.0117 | 0.0601 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0505 | 0.3456 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0117 | 0.0601 | 0.9998 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0117 | 0.0601 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Trypanosoma brucei | trans-sialidase | 0.0117 | 0.0601 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.0117 | 0.0601 | 0.9998 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0117 | 0.0601 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.001 uM | Agonist activity at human recombinant PPARalpha by GAL4 transactivation assay | ChEMBL. | 17553678 |
EC50 (functional) | = 0.001 uM | Agonist activity at human recombinant PPARalpha by GAL4 transactivation assay | ChEMBL. | 17553678 |
EC50 (functional) | = 0.12 uM | Agonist activity at human recombinant PPARdelta by GAL4 transactivation assay | ChEMBL. | 17553678 |
EC50 (functional) | = 0.12 uM | Agonist activity at human recombinant PPARdelta by GAL4 transactivation assay | ChEMBL. | 17553678 |
EC50 (functional) | = 0.21 uM | Agonist activity at human recombinant PPARgamma by GAL4 transactivation assay | ChEMBL. | 17553678 |
EC50 (functional) | = 0.21 uM | Agonist activity at human recombinant PPARgamma by GAL4 transactivation assay | ChEMBL. | 17553678 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.