Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma japonicum | ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus granulosus | glutamate NMDA receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma mansoni | glutamate receptor NMDA | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0212 | 0.0886 | 0.4042 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0105 | 0.0189 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0212 | 0.0886 | 0.4042 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.0533 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0105 | 0.0189 | 1 |
Brugia malayi | LBP/BPI | 0.0157 | 0.0533 | 0.1997 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0212 | 0.0886 | 0.4042 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0105 | 0.0189 | 0.0305 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Schistosoma mansoni | nicalin (M28 family) | 0.0105 | 0.0189 | 0.0305 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.1912 | 0.1756 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0143 | 0.0439 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0105 | 0.0189 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0105 | 0.0189 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0212 | 0.0886 | 0.071 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0212 | 0.0886 | 0.071 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0105 | 0.0189 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0105 | 0.0189 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0369 | 0.1912 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0105 | 0.0189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Onchocerca volvulus | 0.0157 | 0.0533 | 0.1997 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0369 | 0.1912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1068 | 0.6469 | 0.6401 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0105 | 0.0189 | 0.0194 |
Leishmania major | glutaminyl cyclase, putative | 0.0105 | 0.0189 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0212 | 0.0886 | 0.4042 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.103 | 0.6219 | 1 |
Brugia malayi | hypothetical protein | 0.0212 | 0.0886 | 0.4042 |
Brugia malayi | hypothetical protein | 0.0157 | 0.0533 | 0.1997 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0105 | 0.0189 | 0.0305 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0369 | 0.1912 | 0.1756 |
Onchocerca volvulus | 0.0212 | 0.0886 | 0.4042 | |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0105 | 0.0189 | 0.0194 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0105 | 0.0189 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0533 | 0.0351 |
Onchocerca volvulus | 0.0212 | 0.0886 | 0.4042 | |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.1572 | 0.975 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0533 | 0.0351 |
Toxoplasma gondii | hypothetical protein | 0.0105 | 0.0189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1467 | 0.9068 | 0.905 |
Leishmania major | hypothetical protein, conserved | 0.0105 | 0.0189 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0105 | 0.0189 | 0.0305 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0143 | 0.0439 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0369 | 0.1912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0533 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0533 | 0.0351 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 14 nM | Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | ChEMBL. | 17766107 |
Ki (binding) | = 14 nM | Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | ChEMBL. | 17766107 |
t1/2 (ADMET) | = 44 min | Metabolic stability assessed as half life in human liver microsomes | ChEMBL. | 17766107 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.