Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus granulosus | glutamate NMDA receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma japonicum | ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0105 | 0.0189 | 0.0305 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0143 | 0.0439 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0533 | 0.0351 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0369 | 0.1912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0533 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Onchocerca volvulus | 0.0212 | 0.0886 | 0.4042 | |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Leishmania major | glutaminyl cyclase, putative | 0.0105 | 0.0189 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0212 | 0.0886 | 0.4042 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.103 | 0.6219 | 1 |
Brugia malayi | hypothetical protein | 0.0212 | 0.0886 | 0.4042 |
Brugia malayi | hypothetical protein | 0.0157 | 0.0533 | 0.1997 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0369 | 0.1912 | 0.1756 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0105 | 0.0189 | 0.0305 |
Leishmania major | hypothetical protein, conserved | 0.0105 | 0.0189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1467 | 0.9068 | 0.905 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0533 | 0.0351 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0105 | 0.0189 | 0.0194 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0105 | 0.0189 | 0.0194 |
Onchocerca volvulus | 0.0212 | 0.0886 | 0.4042 | |
Toxoplasma gondii | hypothetical protein | 0.0105 | 0.0189 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.1572 | 0.975 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0533 | 0.0351 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0212 | 0.0886 | 0.071 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0105 | 0.0189 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0212 | 0.0886 | 0.071 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0105 | 0.0189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.1912 | 0.1756 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0143 | 0.0439 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0105 | 0.0189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1068 | 0.6469 | 0.6401 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0105 | 0.0189 | 0.0194 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0369 | 0.1912 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0105 | 0.0189 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0105 | 0.0189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Onchocerca volvulus | 0.0157 | 0.0533 | 0.1997 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0369 | 0.1912 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0212 | 0.0886 | 0.4042 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.0533 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0105 | 0.0189 | 1 |
Brugia malayi | LBP/BPI | 0.0157 | 0.0533 | 0.1997 |
Brugia malayi | hypothetical protein | 0.0212 | 0.0886 | 0.4042 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0105 | 0.0189 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Schistosoma mansoni | nicalin (M28 family) | 0.0105 | 0.0189 | 0.0305 |
Onchocerca volvulus | 0.0369 | 0.1912 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0886 | 0.071 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0212 | 0.0886 | 0.4042 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0105 | 0.0189 | 0.0305 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | = 43 % | Bioavailability in rat | ChEMBL. | 17766107 |
IC50 | > 30 uM | Inhibition of hERG | ChEMBL. | 17766107 |
IC50 | > 30 uM | Inhibition of hERG | ChEMBL. | 17766107 |
Inhibition | = 36 % | Inhibition of hERG current at 10 uM | ChEMBL. | 17766107 |
Inhibition | = 36 % | Inhibition of hERG current at 10 uM | ChEMBL. | 17766107 |
Ki (binding) | = 4.2 nM | Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | ChEMBL. | 17766107 |
Ki (binding) | = 4.2 nM | Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | ChEMBL. | 17766107 |
MED (functional) | = 3 mg kg-1 | Analgesic activity in PSL mouse model assessed as latency to paw withdrawal | ChEMBL. | 17766107 |
MED (functional) | = 3 mg kg-1 | Analgesic activity in PSL mouse model assessed as latency to paw withdrawal | ChEMBL. | 17766107 |
t1/2 (ADMET) | = 44 min | Metabolic stability assessed as half life in human liver microsomes | ChEMBL. | 17766107 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.