Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0211 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.018 | 0.6913 | 0.6913 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Onchocerca volvulus | 0.0211 | 1 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0211 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0143 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0211 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0211 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0143 | 0.3182 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0211 | 1 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.018 | 0.6913 | 0.6913 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0211 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0211 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.018 | 0.6913 | 0.6913 |
Onchocerca volvulus | 0.0211 | 1 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0211 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0211 | 1 | 1 |
Onchocerca volvulus | 0.0211 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Onchocerca volvulus | 0.0211 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0143 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0211 | 1 | 1 |
Onchocerca volvulus | 0.0211 | 1 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.018 | 0.6913 | 0.6913 |
Plasmodium vivax | vivapain-2 | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Onchocerca volvulus | 0.0211 | 1 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.0211 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0211 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0211 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0143 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0211 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0211 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0143 | 0.3182 | 0.3182 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.018 | 0.6913 | 0.6913 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0211 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0211 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.018 | 0.6913 | 0.6913 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0211 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.018 | 0.6913 | 0.6913 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0211 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0211 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0211 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0143 | 0.3182 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0211 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0143 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0211 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0211 | 1 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0211 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0211 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0211 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0143 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Onchocerca volvulus | 0.0211 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0211 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0143 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0211 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0211 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.018 | 0.6913 | 0.6913 |
Toxoplasma gondii | cathepsin CPL | 0.0211 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0211 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0211 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0211 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0211 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0211 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0211 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0211 | 1 | 0.5 |
Loa Loa (eye worm) | cysteine protease | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.018 | 0.6913 | 0.6913 |
Onchocerca volvulus | Cathepsin F homolog | 0.0211 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.6913 | 0.5472 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0143 | 0.3182 | 0.3182 |
Echinococcus granulosus | cathepsin b | 0.018 | 0.6913 | 0.6913 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0211 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0211 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 50 uM | Cytotoxicity in the presence of thymidine and hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | = 50 uM | Cytotoxicity in the presence of thymidine and hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | = 51 uM | Cytotoxicity in the absence of thymidine and hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | = 51 uM | Cytotoxicity in the absence of thymidine and hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | = 56 uM | Cytotoxicity in the absence of thymidine and presence of hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | = 56 uM | Cytotoxicity in the absence of thymidine and presence of hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | = 69 uM | Cytotoxicity in the absence of hypoxanthine and presence of thymidine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | = 69 uM | Cytotoxicity in the absence of hypoxanthine and presence of thymidine against CCRF-CEM cell line | ChEMBL. | 10888335 |
Inhibition (binding) | % | In vitro inhibitory activity against Aminoimidazole carboxamide ribonucleotide transformylase pre-incubated for 12 hr at 250 microM; Not active. | ChEMBL. | 10888335 |
Inhibition (binding) | NA 0 % | In vitro inhibitory activity against Aminoimidazole carboxamide ribonucleotide transformylase pre-incubated for 12 hr at 250 microM; Not active. | ChEMBL. | 10888335 |
Inhibition (binding) | = 48 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 1 hr at 250 uM | ChEMBL. | 10888335 |
Inhibition (binding) | = 48 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 1 hr at 250 uM | ChEMBL. | 10888335 |
Inhibition (binding) | = 52 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) following 30 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 52 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) following 30 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 57 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase+GAR) following 30 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 57 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase+GAR) following 30 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 58 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase+GAR) pre-incubation of 6 h at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 58 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase+GAR) pre-incubation of 6 h at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 65 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) following 3 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 65 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) following 3 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 66 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase+GAR) following 3 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 66 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase+GAR) following 3 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.