TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 279.336 | Formula: C17H17N3O
H donors: 1 H acceptors: 2 LogP: 2.28 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)C1C2=C(O)CCCC2=Nc2n1ncc2
InChi: 1S/C17H17N3O/c1-11-4-2-5-12(10-11)17-16-13(6-3-7-14(16)21)19-15-8-9-18-20(15)17/h2,4-5,8-10,17,21H,3,6-7H2,1H3
InChiKey: MCAWTESNIGIVMN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium inwardly-rectifying channel, subfamily J, member 11	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.0098	1
Brugia malayi	G protein-coupled receptor	0.0041	0.0098	0.0075
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Brugia malayi	ORL1-like opioid receptor	0.0041	0.0098	0.0075
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0041	0.0098	1
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Onchocerca volvulus		0.0041	0.0098	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Onchocerca volvulus		0.0041	0.0098	0.5
Brugia malayi	neuropeptide F receptor	0.0041	0.0098	0.0075
Brugia malayi	Dopamine receptor protein 2	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Schistosoma mansoni	histamine h1 receptor	0.0041	0.0098	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.0098	1
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.004	0.0023	0.5
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0041	0.0098	1
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Schistosoma mansoni	amine GPCR	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0041	0.0098	1
Brugia malayi	G-protein coupled receptor	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	G protein coupled receptor 139	0.0041	0.0098	1
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.004	0.0023	0.5
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0098	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0041	0.0098	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0098	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0098	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0041	0.0098	0.0075
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Schistosoma mansoni	myosin xvIII	0.0041	0.0098	1
Onchocerca volvulus		0.0041	0.0098	0.5
Brugia malayi	GnHR receptor homolog	0.0041	0.0098	0.0075
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0098	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0041	0.0098	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0041	0.0098	0.5
Onchocerca volvulus		0.0041	0.0098	0.5
Leishmania major	protein kinase A catalytic subunit	0.004	0.0023	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.0098	1
Brugia malayi	Serotonin receptor	0.0041	0.0098	0.0075
Echinococcus granulosus	7TM GPCR rhodopsin	0.0041	0.0098	1
Echinococcus multilocularis	sex peptide receptor	0.0041	0.0098	1
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.0098	1
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.0098	1
Brugia malayi	larval opioid receptor	0.0041	0.0098	0.0075
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0041	0.0098	1
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0041	0.0098	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0041	0.0098	1
Echinococcus multilocularis	serotonin receptor	0.0041	0.0098	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0041	0.0098	1
Brugia malayi	AKH receptor	0.0041	0.0098	0.0075
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Brugia malayi	RE15519p	0.0041	0.0098	0.0075
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.004	0.0023	0.5
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0098	1
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0098	1
Echinococcus granulosus	neuropeptide s receptor	0.0041	0.0098	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0041	0.0098	1
Schistosoma mansoni	adenoreceptor	0.0041	0.0098	1
Echinococcus multilocularis	serotonin receptor	0.0041	0.0098	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0098	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.0098	1
Echinococcus multilocularis	allatostatin A receptor	0.0041	0.0098	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	neuropeptide receptor A26	0.0041	0.0098	1
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0098	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0041	0.0098	0.0075
Loa Loa (eye worm)	melatonin receptor type 1A	0.0041	0.0098	0.0075
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0098	1
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.0098	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0041	0.0098	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0041	0.0098	0.0075
Echinococcus granulosus	orexin receptor type 2	0.0041	0.0098	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0098	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0023	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.0098	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0098	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0041	0.0098	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0041	0.0098	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.004	0.0023	0.2363
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.004	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0098	1
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.0098	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0023	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus granulosus	sex peptide receptor	0.0041	0.0098	1
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0098	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0237	1	1
Echinococcus granulosus	neuropeptide receptor	0.0041	0.0098	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.004	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.004	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus granulosus	neuropeptide receptor A26	0.0041	0.0098	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0098	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0041	0.0098	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Schistosoma mansoni	amine GPCR	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus granulosus	hypothetical protein	0.0041	0.0098	1
Echinococcus granulosus	neuropeptide receptor	0.0041	0.0098	1
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0098	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.0098	1
Brugia malayi	Dopamine receptor protein 1	0.0041	0.0098	0.0075
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0041	0.0098	0.0075
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.004	0.0023	0.2363
Onchocerca volvulus		0.0041	0.0098	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.0098	1
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0041	0.0098	0.0075
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0041	0.0098	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0098	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0098	1
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.0098	0.0075
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.004	0.0023	0.2363
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0098	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.004	0.0023	0.2363
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0041	0.0098	0.0075
Onchocerca volvulus		0.0041	0.0098	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Brugia malayi	Melatonin receptor type 1A	0.0041	0.0098	0.0075
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0041	0.0098	1
Onchocerca volvulus		0.0041	0.0098	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.0098	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0041	0.0098	1
Echinococcus granulosus	serotonin receptor	0.0041	0.0098	1
Schistosoma mansoni	amine GPCR	0.0041	0.0098	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Brugia malayi	G-protein coupled receptor	0.0041	0.0098	0.0075
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.0098	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0041	0.0098	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0041	0.0098	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0041	0.0098	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Onchocerca volvulus		0.0041	0.0098	0.5
Onchocerca volvulus		0.0041	0.0098	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0098	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0098	1
Onchocerca volvulus		0.0041	0.0098	0.5
Brugia malayi	neuropeptide F receptor	0.0041	0.0098	0.0075
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0098	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0041	0.0098	1
Brugia malayi	Serotonin receptor	0.0041	0.0098	0.0075
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	g-protein coupled receptor	0.0041	0.0098	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.0098	0.0075
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.0098	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.004	0.0023	0.2363
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.0098	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.0098	1
Onchocerca volvulus		0.0041	0.0098	0.5
Schistosoma mansoni	amine GPCR	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Brugia malayi	sulfakinin receptor protein	0.0041	0.0098	0.0075
Echinococcus granulosus	fmrfamide receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.318	0.3164
Echinococcus granulosus	allatostatin A receptor	0.0041	0.0098	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0041	0.0098	0.0075
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0098	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0041	0.0098	1
Schistosoma mansoni	opsin-like receptor	0.0041	0.0098	1
Loa Loa (eye worm)	TYRA-2 protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.004	0.0023	0.5
Echinococcus multilocularis	somatostatin receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0098	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.0098	1
Schistosoma mansoni	opsin-like receptor	0.0041	0.0098	1
Giardia lamblia	Kinase, AGC PKA	0.004	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0041	0.0098	1
Brugia malayi	Dopamine receptor	0.0041	0.0098	0.0075
Onchocerca volvulus		0.0041	0.0098	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus multilocularis	neuropeptide s receptor	0.0041	0.0098	1
Echinococcus granulosus	g-protein coupled receptor	0.0041	0.0098	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Brugia malayi	putative neuropeptide receptor	0.0041	0.0098	0.0075
Onchocerca volvulus		0.0041	0.0098	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0041	0.0098	0.0075
Echinococcus granulosus	somatostatin receptor	0.0041	0.0098	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0041	0.0098	1
Onchocerca volvulus		0.0041	0.0098	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Schistosoma mansoni	opsin-like receptor	0.0041	0.0098	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.0098	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0102	0.318	0.3164
Schistosoma mansoni	hypothetical protein	0.0041	0.0098	1
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0098	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Leishmania major	protein kinase A catalytic subunit isoform 2	0.004	0.0023	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0041	0.0098	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Brugia malayi	putative neuropeptide receptor NPR1	0.0041	0.0098	0.0075
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0041	0.0098	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.004	0.0023	0.2363
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0041	0.0098	0.0075
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0041	0.0098	0.0075
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0098	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0098	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0041	0.0098	1
Onchocerca volvulus		0.0041	0.0098	0.5
Schistosoma mansoni	hypothetical protein	0.0041	0.0098	1
Echinococcus multilocularis	orexin receptor type 2	0.0041	0.0098	1
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.0098	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0041	0.0098	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0098	1
Brugia malayi	hypothetical protein	0.0041	0.0098	0.0075
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0041	0.0098	0.0075
Echinococcus granulosus	7tm_1 domain containing protein	0.0041	0.0098	1
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0098	1
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.004	0.0023	0.5
Leishmania major	protein kinase A catalytic subunit isoform 1	0.004	0.0023	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.0098	1
Brugia malayi	follicle stimulating hormone receptor	0.0041	0.0098	0.0075
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0098	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0098	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0237	1	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.318	0.3164
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.004	0.0023	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0098	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.004	0.0023	0.2363
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0098	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0041	0.0098	1
Schistosoma mansoni	amine GPCR	0.0041	0.0098	1
Onchocerca volvulus		0.0041	0.0098	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.0098	0.0075
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0041	0.0098	0.0075
Schistosoma mansoni	neuropeptide f receptor 76f	0.0041	0.0098	1
Toxoplasma gondii	hypothetical protein	0.0102	0.318	1
Echinococcus granulosus	G protein coupled receptor 139	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Onchocerca volvulus		0.0041	0.0098	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.0098	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0102	0.318	0.3164
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0098	0.0075
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0098	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 10000 nM	Potassium channel opening activity determined in cultured guinea pig urinary bladder cells	ChEMBL.	12031324
EC50 (functional)	> 10000 nM	Potassium channel opening activity determined in cultured guinea pig urinary bladder cells	ChEMBL.	12031324

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 48323