Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2006 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0812 | 0.2628 | 0.1795 |
Onchocerca volvulus | 0.0812 | 0.2628 | 0.1795 | |
Brugia malayi | thymidylate synthase | 0.0812 | 0.2628 | 0.2628 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0551 | 0.1015 | 0.2173 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0812 | 0.2628 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0812 | 0.2628 | 0.5 |
Onchocerca volvulus | 0.2006 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.2006 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0386 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2006 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0812 | 0.2628 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2006 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0812 | 0.2628 | 0.1795 |
Onchocerca volvulus | 0.1762 | 0.8494 | 0.8324 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1143 | 0.4672 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0812 | 0.2628 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0551 | 0.1015 | 0.1015 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1143 | 0.4672 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0551 | 0.1015 | 0.1015 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1143 | 0.4672 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1143 | 0.4672 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1143 | 0.4672 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1143 | 0.4672 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0812 | 0.2628 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.017 uM | Inhibitory potency against mitogen activated protein kinase kinase kinase 1 | ChEMBL. | 15006386 |
IC50 (binding) | = 0.017 uM | Inhibitory potency against mitogen activated protein kinase kinase kinase 1 | ChEMBL. | 15006386 |
IC50 (functional) | = 2.4 uM | Inhibitory concentration against AP-1 transcription in COS-7 cells | ChEMBL. | 15006386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.