Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | colony stimulating factor 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | Get druggable targets OG5_132967 | All targets in OG5_132967 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | twitchin | 0.0014 | 0.0043 | 0.0043 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0021 | 0.0189 | 1 |
Schistosoma mansoni | deoxyribonuclease 1 related | 0.0143 | 0.2684 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0043 | 0.0992 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0033 | 0.0433 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0019 | 0.0137 | 0.0137 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0033 | 0.0433 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0014 | 0.0043 | 0.016 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.0433 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0014 | 0.0043 | 0.016 |
Echinococcus granulosus | deoxyribonuclease 1 | 0.0143 | 0.2684 | 0.2684 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0043 | 0.0992 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0014 | 0.0043 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0137 | 0.3151 |
Echinococcus multilocularis | deoxyribonuclease 1 2 | 0.0146 | 0.2738 | 1 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0021 | 0.0189 | 0.0705 |
Echinococcus multilocularis | deoxyribonuclease 1 2 | 0.0143 | 0.2684 | 0.9803 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0137 | 0.3151 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0043 | 0.0157 |
Echinococcus granulosus | deoxyribonuclease 1 | 0.0143 | 0.2684 | 0.2684 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0043 | 0.0992 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0021 | 0.0189 | 1 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0043 | 0.016 |
Echinococcus multilocularis | protein arginine N methyltransferase 8 | 0.0021 | 0.0189 | 0.0691 |
Toxoplasma gondii | histone arginine methyltransferase PRMT1 | 0.0021 | 0.0189 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0014 | 0.0043 | 0.0992 |
Echinococcus multilocularis | Immunoglobulin | 0.0014 | 0.0043 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0043 | 0.0992 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0043 | 0.0992 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0137 | 0.3151 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0019 | 0.0137 | 0.0137 |
Echinococcus multilocularis | Immunoglobulin | 0.0014 | 0.0043 | 0.0157 |
Echinococcus multilocularis | protein arginine methyltransferase | 0.0021 | 0.0189 | 0.0691 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.002 | 0.0163 | 0.3753 |
Echinococcus granulosus | protein arginine methyltransferase | 0.0021 | 0.0189 | 0.0189 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0021 | 0.0189 | 0.0705 |
Leishmania major | arginine N-methyltransferase-like protein | 0.0021 | 0.0189 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0163 | 0.3753 |
Echinococcus multilocularis | deoxyribonuclease | 0.0143 | 0.2684 | 0.9803 |
Echinococcus granulosus | Immunoglobulin | 0.0014 | 0.0043 | 0.0043 |
Plasmodium vivax | protein arginine N-methyltransferase 1, putative | 0.0021 | 0.0189 | 0.5 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0014 | 0.0043 | 0.0157 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0043 | 0.0992 |
Echinococcus granulosus | deoxyribonuclease 1 | 0.0143 | 0.2684 | 0.2684 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0033 | 0.0433 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0014 | 0.0043 | 0.0043 |
Echinococcus multilocularis | roundabout 2 | 0.0019 | 0.0137 | 0.0499 |
Echinococcus multilocularis | deoxyribonuclease | 0.0143 | 0.2684 | 0.9803 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0043 | 0.0992 |
Echinococcus granulosus | protein arginine N methyltransferase 8 | 0.0021 | 0.0189 | 0.0189 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0033 | 0.0433 | 1 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0021 | 0.0189 | 0.0705 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0043 | 0.0992 |
Plasmodium falciparum | protein arginine N-methyltransferase 1 | 0.0021 | 0.0189 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0019 | 0.0137 | 0.0509 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0021 | 0.0189 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 uM | Inhibition of cfms | ChEMBL. | 17870531 |
IC50 (binding) | = 0.1 uM | Inhibition of cfms | ChEMBL. | 17870531 |
IC50 (functional) | = 4 uM | Growth inhibition of MCSF expressing mouse M-NSF60 cells | ChEMBL. | 17870531 |
IC50 (functional) | = 10 uM | Growth inhibition of MCSF-independent mouse NSO cells | ChEMBL. | 17870531 |
IC50 (functional) | = 10 uM | Growth inhibition of MCSF-independent mouse NSO cells | ChEMBL. | 17870531 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 17870531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.