Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0059 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0059 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0059 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0046 | 0.7796 | 0.0014 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0059 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0059 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0059 | 1 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0059 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0059 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0059 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0059 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.7796 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0059 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0059 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.7796 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0059 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0059 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0059 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0059 | 1 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0046 | 0.7796 | 0.0014 |
Echinococcus granulosus | carbonic anhydrase | 0.0059 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0059 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0059 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0059 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0059 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0059 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0059 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0059 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 75 nM | Inhibition of human CDS1 using N-terminal biotin labeled SGLYRSPSMPENLNRPR as substrate in presence of [gamma-33P]-ATP after 3 hrs by scintillation counting method | PATENT. | No reference |
IC50 (binding) | = 180 nM | Inhibition of human recombinant Chk2 | ChEMBL. | 17937984 |
IC50 (binding) | = 180 nM | Inhibition of human recombinant Chk2 | ChEMBL. | 17937984 |
Solubility | 0 | Solubility in stimulated inestinal fluid at pH 7 after 3 days | ChEMBL. | 17937984 |
Solubility | 0 | Solubility in stimulated gastric fluid at pH 2 umol after 3 days | ChEMBL. | 17937984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.