Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei gambiense | cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative | References | |
Trypanosoma brucei | cysteine peptidase C (CPC) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 2b | cysteine peptidase C (CPC) | 340 aa | 321 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Cathepsin B precursor | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0164 | 0.5 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0164 | 0.5 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0164 | 0.5 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0164 | 0.5 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0164 | 0.5 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0164 | 0.5 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0164 | 0.5 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0164 | 0.5 | 0.5 |
Toxoplasma gondii | cathepsin B | 0.0164 | 0.5 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0164 | 0.5 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0164 | 0.5 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0164 | 0.5 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0164 | 0.5 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0164 | 0.5 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0164 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.26 uM | Antitrypanosomal activity against Trypanosoma brucei | ChEMBL. | 18173229 |
IC50 (functional) | = 0.26 uM | Antitrypanosomal activity against Trypanosoma brucei | ChEMBL. | 18173229 |
IC50 (binding) | = 2.8 uM | Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease | ChEMBL. | 18173229 |
IC50 (binding) | = 2.8 uM | Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease | ChEMBL. | 18173229 |
IC50 (binding) | > 30 uM | Inhibition of human liver cathepsin L | ChEMBL. | 18173229 |
IC50 (binding) | > 30 uM | Inhibition of human liver cathepsin B | ChEMBL. | 18173229 |
IC50 (binding) | > 30 uM | Inhibition of human liver cathepsin L | ChEMBL. | 18173229 |
IC50 (binding) | > 30 uM | Inhibition of human liver cathepsin B | ChEMBL. | 18173229 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 18173229 | ||
Trypanosoma brucei | ChEMBL23 | 18173229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.