Detailed information for compound 501741

Basic information

Technical information
  • TDR Targets ID: 501741
  • Name: ethyl (4S)-4-(3-hydroxyphenyl)-6-methyl-2-sul fanylidene-3,4-dihydro-1H-pyrimidine-5-carbox ylate
  • MW: 292.353 | Formula: C14H16N2O3S
  • H donors: 3 H acceptors: 2 LogP: 1.62 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(C)NC(=S)N[C@H]1c1cccc(c1)O
  • InChi: 1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)/t12-/m0/s1
  • InChiKey: LOBCDGHHHHGHFA-LBPRGKRZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl (4S)-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
  • (4S)-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
  • monastrol
  • 254753-54-3
  • NAT
  • ZINC00297106
  • 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester, (4S)- (9CI)
  • ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
  • (S)-Monastrol
  • nchembio.2007.34-comp3
  • (4S)-Monastrol
  • ZINC04425506
  • 5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester, (4S)-
  • Group III Compounds: 10

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinesin family member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Brugia malayi Kinesin motor domain containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma japonicum ko:K10398 kinesin family member 11, putative Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium parvum kinesin-like boursin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus multilocularis kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Neospora caninum hypothetical protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium knowlesi kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Toxoplasma gondii kinesin motor domain-containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium falciparum kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Loa Loa (eye worm) kinesin-like protein KLP2 Get druggable targets OG5_128460 All targets in OG5_128460
Giardia lamblia Kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium vivax kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium yoelii Kinesin motor domain, putative Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma mansoni kinesin eg-5 Get druggable targets OG5_128460 All targets in OG5_128460
Entamoeba histolytica kinesin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium hominis kinesin-like boursin Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus granulosus kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.036 0.0438
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.7118 0.7118
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0165 0.0201
Schistosoma mansoni polycystin 1-related 0.0024 0.0238 0.0238
Echinococcus granulosus GPCR family 2 0.0015 0.0098 0.0098
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0079 0.1105 1
Loa Loa (eye worm) hypothetical protein 0.0535 0.822 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0098 0.0098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.0599 0.0728
Echinococcus multilocularis microtubule associated protein 2 0.0649 1 1
Echinococcus granulosus dnaJ subfamily B 0.0464 0.7118 0.7118
Echinococcus multilocularis GPCR, family 2 0.0015 0.0098 0.0098
Schistosoma mansoni lipoxygenase 0.0024 0.0238 0.0238
Echinococcus multilocularis cpg binding protein 0.0034 0.0405 0.0405
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0015 0.0094 0.0849
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1012 0.1012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0599 0.0728
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0015 0.0094 0.0849
Schistosoma mansoni lozenge 0.0067 0.0914 0.0914
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1012 0.1012
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.1037 1
Onchocerca volvulus 0.0033 0.0376 0.0389
Brugia malayi hypothetical protein 0.0535 0.822 1
Echinococcus granulosus cpg binding protein 0.0034 0.0405 0.0405
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1012 0.1012
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0869 0.0869
Loa Loa (eye worm) hypothetical protein 0.0535 0.822 1
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0544 0.0544
Plasmodium vivax kinesin-5 0.0032 0.0369 1
Brugia malayi hypothetical protein 0.0012 0.0058 0.0071
Echinococcus multilocularis kinesin family 1 0.0247 0.3732 0.3732
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1012 0.9154
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0019 0.0161 0.2216
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1037 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0015 0.0094 0.0849
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.1037 0.1261
Schistosoma mansoni cpg binding protein 0.0033 0.0376 0.0376
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0098 0.0098
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0019 0.0161 0.1564
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0521 0.5028
Loa Loa (eye worm) RNA binding protein 0.0064 0.0869 0.1057
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0022 0.0027
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0058 0.056
Brugia malayi hypothetical protein 0.0024 0.0238 0.029
Schistosoma mansoni loxhd1 0.0024 0.0238 0.0238
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0058 0.056
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1037 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0058 0.0058
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0098 0.0119
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0098
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0869 0.1057
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0039
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0367 0.0446
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0521 1
Schistosoma mansoni rab6-interacting 0.0024 0.0238 0.0238
Brugia malayi TAR-binding protein 0.0064 0.0869 0.1057
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0544 0.0544
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.0599 0.0728
Onchocerca volvulus 0.0535 0.822 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0165 0.0201
Leishmania major cytochrome p450-like protein 0.0019 0.0165 0.1594
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0058 0.0058
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0165 0.1495
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0015 0.0094 0.0849
Schistosoma mansoni microtubule-associated protein tau 0.0649 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0831 0.8215
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.1037 0.1037
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.1037 0.1261
Schistosoma mansoni lipoxygenase 0.0067 0.0908 0.0908
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0019 0.0161 0.2216
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0521 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0908 0.0908
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0521 0.5028
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.1037 0.1037
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0015 0.0094 0.0849
Loa Loa (eye worm) hypothetical protein 0.0015 0.0098 0.0119
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0869 0.1057
Echinococcus granulosus tar DNA binding protein 0.0064 0.0869 0.0869
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.1037 0.1037
Schistosoma mansoni inositol monophosphatase 0.0042 0.0521 0.0521
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0908 0.0908
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0071
Mycobacterium tuberculosis Two component sensor kinase [first part] 0.0011 0.0034 0.0305
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0521 0.5153
Loa Loa (eye worm) hypothetical protein 0.0032 0.0367 0.0446
Schistosoma mansoni hypothetical protein 0.0024 0.0238 0.0238
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0453 0.4096
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0058 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1012 0.9154
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0238 0.0238
Schistosoma mansoni rab6-interacting 0.0024 0.0238 0.0238
Toxoplasma gondii kinesin motor domain-containing protein 0.0032 0.0369 0.3644
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1012 0.1012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0098 0.0098
Echinococcus granulosus RUN 0.0024 0.0238 0.0238
Brugia malayi Inositol-1 0.0042 0.0521 0.0634
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0521 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0165 0.1594
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0165 0.0201
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0079 0.1105 1
Brugia malayi RNA binding protein 0.0064 0.0869 0.1057
Brugia malayi hypothetical protein 0.0024 0.0238 0.029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1012 0.9154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0098 0.0098
Onchocerca volvulus 0.0024 0.0238 0.0221
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0058 0.056
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0098 0.0119
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0869 0.0869
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0521 0.0521
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0058 0.056
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0165 0.1594
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0019 0.0161 0.2216
Schistosoma mansoni inositol monophosphatase 0.0042 0.0521 0.0521
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0058 0.0071
Onchocerca volvulus 0.0024 0.0238 0.0221
Trichomonas vaginalis receptor histidine kinase, putative 0.0019 0.0161 0.2216
Loa Loa (eye worm) inositol-1 0.0042 0.0521 0.0634
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0376 0.0457
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1012 0.9154
Leishmania major protein kinase, putative 0.0012 0.0058 0.056
Mycobacterium ulcerans two component regulator - sensor kinase 0.0015 0.0094 0.0849
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0015 0.0094 0.0849
Plasmodium falciparum kinesin-5 0.0032 0.0369 1
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0098
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0521 0.2285
Loa Loa (eye worm) hypothetical protein 0.0024 0.0238 0.029
Echinococcus multilocularis Protein lozenge 0.0067 0.0914 0.0914
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0058 0.056
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0521 0.0521
Trichomonas vaginalis sensor histidine kinase, putative 0.0019 0.0161 0.2216
Echinococcus multilocularis RUN 0.0024 0.0238 0.0238
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0019 0.0161 0.2216
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0453 0.4096
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1012 1
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0015 0.0094 0.0849
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0869 0.0869
Loa Loa (eye worm) histone methyltransferase 0.001 0.0024 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0869 0.0869
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0521 1
Schistosoma mansoni hypothetical protein 0.0464 0.7118 0.7118
Giardia lamblia Kinesin-5 0.0032 0.0369 0.5
Brugia malayi Cytochrome P450 family protein 0.0032 0.036 0.0438
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0079 0.1105 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0015 0.0094 0.0849
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0869 0.0869
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0058 0.0058
Leishmania major protein kinase, putative 0.0012 0.0058 0.056
Brugia malayi Cytochrome P450 family protein 0.0019 0.0165 0.0201
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0092 0.1297 0.5
Brugia malayi PAS domain containing protein 0.0012 0.0058 0.0071
Schistosoma mansoni kinesin eg-5 0.0032 0.0369 0.0369
Loa Loa (eye worm) runx1 0.0067 0.0914 0.1112
Mycobacterium leprae Probable two component sensor kinase MprB 0.0015 0.0094 0.0849
Schistosoma mansoni cpg binding protein 0.0034 0.0405 0.0405
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0238 0.029
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0165 0.1594
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0946 0.0946
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0238 0.0238
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0238 0.0238
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0015 0.0094 0.0849
Schistosoma mansoni hypothetical protein 0.0015 0.0098 0.0098
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0521 0.5028
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0015 0.0094 0.0849
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1037 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0869 0.1057
Schistosoma mansoni cpg binding protein 0.0034 0.0405 0.0405
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0024 0.0024
Mycobacterium leprae Possible regulatory protein 0.0012 0.0058 0.0525
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0238 0.0238
Brugia malayi Doublecortin family protein 0.0024 0.0238 0.029
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0015 0.0094 0.0849
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0238 0.0238
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0165 0.0201
Echinococcus granulosus kinesin family 1 0.0247 0.3732 0.3732
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0521 0.4717
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0869 0.0869
Mycobacterium ulcerans two component sensor kinase MprB 0.0015 0.0094 0.0849
Schistosoma mansoni single-minded 0.0012 0.0058 0.0058
Schistosoma mansoni aryl hydrocarbon receptor 0.0012 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0012 0.0058 0.0071
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0098 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0238 0.029
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0058 0.056
Schistosoma mansoni hypothetical protein 0.0032 0.0367 0.0367
Schistosoma mansoni hypothetical protein 0.0215 0.323 0.323
Brugia malayi CXXC zinc finger family protein 0.0033 0.0376 0.0457
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0024 0.0024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0521 0.5028
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0058 0.056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.0599 0.0728
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1012 0.9758
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0238 0.0238
Trichomonas vaginalis receptor histidine kinase, putative 0.0019 0.0161 0.2216
Brugia malayi Kinesin motor domain containing protein 0.0032 0.0369 0.0448
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.1037 1
Loa Loa (eye worm) kinesin-like protein KLP2 0.0032 0.0369 0.0448
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0079 0.1105 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 29.6 ug ml-1 Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay ChEMBL. 22410248
IC50 (binding) = 10000 nM In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay (n=3) ChEMBL. 15808464
IC50 (binding) = 10000 nM Inhibition of KSP (unknown origin) ChEMBL. 17095225
IC50 (binding) = 10000 nM In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay (n=3) ChEMBL. 15808464
IC50 (binding) = 10000 nM Inhibition of KSP (unknown origin) ChEMBL. 17095225
Inhibition (binding) = 0 % Inhibition pig alpha-amylase at 50 to 300 ug/ml pretreated for 30 mins followed by addition of 1% starch for 10 mins by spectrometer ChEMBL. 24835627

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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