Ki (binding)
|
= 12 nM
|
Displacement of [3H]PDBu from PKCtheta C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 12 nM
|
Displacement of [3H]PDBu from PKCtheta C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 15 nM
|
Displacement of [3H]PDBu from PKCdelta C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 15 nM
|
Displacement of [3H]PDBu from PKCdelta C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 25 nM
|
Displacement of [3H]PDBu from PKCeta C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 25 nM
|
Displacement of [3H]PDBu from PKCeta C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 29 nM
|
Displacement of [3H]PDBu from PKCepsilon C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 29 nM
|
Displacement of [3H]PDBu from PKCepsilon C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 120 nM
|
Displacement of [3H]PDBu from PKCdelta C1B P11dfP mutant (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 420 nM
|
Displacement of [3H]PDBu from PKCgamma C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 420 nM
|
Displacement of [3H]PDBu from PKCgamma C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 440 nM
|
Displacement of [3H]PDBu from PKCbeta C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 440 nM
|
Displacement of [3H]PDBu from PKCbeta C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 6700 nM
|
Displacement of [3H]PDBu from PKCalpha C1A domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 6700 nM
|
Displacement of [3H]PDBu from PKCalpha C1A domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 9200 nM
|
Displacement of [3H]PDBu from PKCbeta C1A domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 9200 nM
|
Displacement of [3H]PDBu from PKCbeta C1A domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
> 10000 nM
|
Displacement of [3H]PDBu from PKCalpha C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
> 10000 nM
|
Displacement of [3H]PDBu from PKCalpha C1B domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 11000 nM
|
Displacement of [3H]PDBu from PKCgamma C1A domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 11000 nM
|
Displacement of [3H]PDBu from PKCgamma C1A domain (unknown origin)
|
ChEMBL.
|
18072722
|
Ki (binding)
|
= 14000 nM
|
Displacement of [3H]PDBu from PKCgamma C1A P11dfP mutant (unknown origin)
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
|
Induction of GFP-tagged PKCepsilon (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
|
Induction of GFP-tagged PKCalpha (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
|
Induction of GFP-tagged PKCgamma (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
|
Induction of GFP-tagged PKCbeta1 (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
|
Induction of GFP-tagged PKCalpha (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
|
Induction of GFP-tagged PKCdelta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
|
Induction of GFP-tagged PKCeta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
|
Induction of GFP-tagged PKCgamma (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 0.97
|
Induction of GFP-tagged PKCalpha (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 0.99
|
Induction of GFP-tagged PKCgamma (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.03
|
Induction of GFP-tagged PKCbeta1 (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.18
|
Induction of GFP-tagged PKCbeta1 (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.4
|
Induction of GFP-tagged PKCbeta1 (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.58
|
Induction of GFP-tagged PKCdelta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.6
|
Induction of GFP-tagged PKCgamma (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.65
|
Induction of GFP-tagged PKCdelta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.75
|
Induction of GFP-tagged PKCeta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.77
|
Induction of GFP-tagged PKCalpha (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.84
|
Induction of GFP-tagged PKCeta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.15
|
Induction of GFP-tagged PKCeta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.19
|
Induction of GFP-tagged PKCdelta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.47
|
Induction of GFP-tagged PKCepsilon (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.5
|
Induction of GFP-tagged PKCepsilon (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.95
|
Induction of GFP-tagged PKCepsilon (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
0
|
Induction of GFP-tagged PKCalpha (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
0
|
Induction of GFP-tagged PKCalpha (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
0
|
Induction of GFP-tagged PKCbeta1 (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
0
|
Induction of GFP-tagged PKCgamma (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
0
|
Induction of GFP-tagged PKCgamma (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
0
|
Induction of GFP-tagged PKCdelta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
0
|
Induction of GFP-tagged PKCepsilon (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
0
|
Induction of GFP-tagged PKCeta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 0.97
|
Induction of GFP-tagged PKCalpha (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 0.99
|
Induction of GFP-tagged PKCgamma (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.03
|
Induction of GFP-tagged PKCbeta1 (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.18
|
Induction of GFP-tagged PKCbeta1 (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.4
|
Induction of GFP-tagged PKCbeta1 (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.58
|
Induction of GFP-tagged PKCdelta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.6
|
Induction of GFP-tagged PKCgamma (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.65
|
Induction of GFP-tagged PKCdelta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.75
|
Induction of GFP-tagged PKCeta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.77
|
Induction of GFP-tagged PKCalpha (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 10 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 1.84
|
Induction of GFP-tagged PKCeta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.15
|
Induction of GFP-tagged PKCeta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.19
|
Induction of GFP-tagged PKCdelta (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.47
|
Induction of GFP-tagged PKCepsilon (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 100 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.5
|
Induction of GFP-tagged PKCepsilon (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 500 nM
|
ChEMBL.
|
18072722
|
Ratio (binding)
|
= 2.95
|
Induction of GFP-tagged PKCepsilon (unknown origin) translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM
|
ChEMBL.
|
18072722
|
Ratio Ki (binding)
|
= 1.3
|
Selectivity ratio of PKCgamma C1A domain (unknown origin) over PKCgamma C1A P11dfP mutant (unknown origin)
|
ChEMBL.
|
18072722
|
Ratio Ki (binding)
|
= 8
|
Selectivity ratio of PKCdelta C1B domain (unknown origin) over PKCdelta C1B P11dfP mutant (unknown origin)
|
ChEMBL.
|
18072722
|