Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0216 | 0.8996 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0156 | 0.0156 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.98 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.0216 | 0.8996 | 1 |
Giardia lamblia | CDC72 | 0.0216 | 0.8996 | 0.5 |
Leishmania major | N-myristoyl transferase, putative | 0.0216 | 0.8996 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0156 | 0.0156 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0216 | 0.8996 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0216 | 0.8996 | 1 |
Brugia malayi | N-myristoyltransferase 2 | 0.0216 | 0.8996 | 0.898 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0156 | 0.0156 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0065 | 0.1558 | 0.1585 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0156 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0156 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0156 | 0.5 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0216 | 0.8996 | 0.5 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0216 | 0.8996 | 1 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0098 | 0.3191 | 0.3433 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0156 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0156 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0156 | 0.5 | |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0098 | 0.3191 | 0.3433 |
Brugia malayi | Transient-receptor-potential like protein | 0.0036 | 0.0161 | 0.0005 |
Schistosoma mansoni | transient receptor potential channel | 0.0065 | 0.1558 | 0.1585 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0236 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0156 | 0.5 | |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0216 | 0.8996 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0156 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0161 | 0.0161 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0057 | 0.1161 | 0.1137 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0095 | 0.303 | 0.3251 |
Schistosoma mansoni | transient receptor potential channel | 0.0098 | 0.3191 | 0.3433 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0098 | 0.3191 | 0.3433 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0036 | 0.0161 | 0.0005 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0156 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0065 | 0.1558 | 0.1585 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.3191 | 0.3191 |
Onchocerca volvulus | 0.0036 | 0.0156 | 0.5 | |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0065 | 0.1558 | 0.1585 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0156 | 0.0156 |
Schistosoma mansoni | transient receptor potential channel | 0.0065 | 0.1558 | 0.1585 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0216 | 0.8996 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0156 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0142 | 0.5351 | 0.5876 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0216 | 0.8996 | 0.8996 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1397 | 0.1397 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0156 | 0.0156 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0095 | 0.303 | 0.3251 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0216 | 0.8996 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0216 | 0.8996 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0065 | 0.1558 | 0.1585 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0156 | 0.0156 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0057 | 0.1161 | 0.1137 |
Trypanosoma brucei | N-myristoyltransferase | 0.0216 | 0.8996 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0156 | 0.0156 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0036 | 0.0161 | 0.0005 |
Schistosoma mansoni | lipoxygenase | 0.0057 | 0.1161 | 0.1137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.3 uM | Inhibition of Candida albicans N-myristoyltransferse | ChEMBL. | 17349719 |
IC50 (binding) | = 2.3 uM | Inhibition of Candida albicans N-myristoyltransferse | ChEMBL. | 17349719 |
Log IC50 (binding) | = -0.362 uM | Inhibition of Candida albicans N-myristoyltransferse | ChEMBL. | 17349719 |
Log IC50 (binding) | = -0.362 uM | Inhibition of Candida albicans N-myristoyltransferse | ChEMBL. | 17349719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.