Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.1685 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.006 | 0.1521 | 0.064 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.1685 | 0.085 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0216 | 0.8783 | 0.8783 |
Brugia malayi | N-myristoyltransferase 2 | 0.0216 | 0.8783 | 0.8783 |
Giardia lamblia | CDC72 | 0.0216 | 0.8783 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.1685 | 0.085 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.1025 | 0.1025 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0216 | 0.8783 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.1685 | 0.0193 |
Leishmania major | N-myristoyl transferase, putative | 0.0216 | 0.8783 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.0216 | 0.8783 | 1 |
Onchocerca volvulus | 0.0049 | 0.1025 | 0.5 | |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0216 | 0.8783 | 0.5 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0216 | 0.8783 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 1 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0216 | 0.8783 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0216 | 0.8783 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0216 | 0.8783 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0216 | 0.8783 | 0.5 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.1521 | 0.1521 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0216 | 0.8783 | 0.5 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0216 | 0.8783 | 0.8565 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.1685 | 1 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0216 | 0.8783 | 0.8565 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.1685 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.1333 | 0.1333 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.1685 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.1685 | 0.0193 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.1685 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.1685 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Inhibition of Candida albicans N-myristoyltransferse | ChEMBL. | 17349719 |
IC50 (binding) | > 10 uM | Inhibition of Candida albicans N-myristoyltransferse | ChEMBL. | 17349719 |
Log IC50 (binding) | = -1 uM | Inhibition of Candida albicans N-myristoyltransferse | ChEMBL. | 17349719 |
Log IC50 (binding) | = -1 uM | Inhibition of Candida albicans N-myristoyltransferse | ChEMBL. | 17349719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.