Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0333463 | 0.860851 | 0.860851 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0280894 | 0.719199 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.00691558 | 0.148652 | 0.148652 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00507889 | 0.0991606 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0385103 | 1 | 1 |
Brugia malayi | amidase | 0.0110148 | 0.25911 | 0.25911 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.00139891 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.00507889 | 0.0991606 | 0.137876 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0385103 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0385103 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0250554 | 0.637445 | 0.886326 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.010676 | 0.249981 | 0.249981 |
Mycobacterium tuberculosis | Hypothetical protein | 0.00507889 | 0.0991606 | 0.0991606 |
Schistosoma mansoni | amidase | 0.0110148 | 0.25911 | 0.25911 |
Loa Loa (eye worm) | hypothetical protein | 0.00691558 | 0.148652 | 0.148652 |
Onchocerca volvulus | 0.010676 | 0.249981 | 1 | |
Mycobacterium ulcerans | thymidylate synthase | 0.010676 | 0.249981 | 0.249981 |
Loa Loa (eye worm) | serotonin transporter b | 0.00691558 | 0.148652 | 0.148652 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0333463 | 0.860851 | 0.860851 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0110148 | 0.25911 | 0.25911 |
Echinococcus multilocularis | serotonin transporter | 0.00691558 | 0.148652 | 0.148652 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0110148 | 0.25911 | 0.25911 |
Echinococcus granulosus | dihydrofolate reductase | 0.0385103 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.00691558 | 0.148652 | 0.148652 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0385103 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.00691558 | 0.148652 | 0.148652 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0280894 | 0.719199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00691558 | 0.148652 | 0.148652 |
Loa Loa (eye worm) | thymidylate synthase | 0.010676 | 0.249981 | 0.249981 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.00691558 | 0.148652 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.00691558 | 0.148652 | 0.148652 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0385103 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0333463 | 0.860851 | 0.860851 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0333463 | 0.860851 | 0.860851 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0280894 | 0.719199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0110148 | 0.25911 | 0.25911 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0110148 | 0.25911 | 0.25911 |
Trypanosoma brucei | pteridine reductase 1 | 0.0249526 | 0.634676 | 0.882476 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0385103 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.010676 | 0.249981 | 0.249981 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.010676 | 0.249981 | 0.249981 |
Loa Loa (eye worm) | hypothetical protein | 0.00691558 | 0.148652 | 0.148652 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0385103 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0110148 | 0.25911 | 0.25911 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.010676 | 0.249981 | 0.249981 |
Schistosoma mansoni | dihydrofolate reductase | 0.0385103 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0385103 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0333463 | 0.860851 | 0.860851 |
Echinococcus multilocularis | thymidylate synthase | 0.010676 | 0.249981 | 0.249981 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0280894 | 0.719199 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0110148 | 0.25911 | 0.25911 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0280894 | 0.719199 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.00691558 | 0.148652 | 0.148652 |
Brugia malayi | thymidylate synthase | 0.010676 | 0.249981 | 0.249981 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0280894 | 0.719199 | 1 |
Brugia malayi | hypothetical protein | 0.00507889 | 0.0991606 | 0.0991606 |
Echinococcus granulosus | serotonin transporter | 0.00691558 | 0.148652 | 0.148652 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 17625894 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.