Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 0.314 | 0.4085 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | nuclear hormone receptor | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0081 | 0.0105 |
Brugia malayi | steroid hormone receptor | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0081 | 0.0105 |
Brugia malayi | ecdysteroid receptor | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1148 | 0.1493 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | carbonic anhydrase | 0.0409 | 0.314 | 0.4085 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0409 | 0.314 | 0.4085 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0409 | 0.314 | 0.4085 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0409 | 0.314 | 0.4085 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0409 | 0.314 | 0.4085 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0036 | 0.0081 | 0.0105 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1246 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0329 | 0.0428 |
Echinococcus multilocularis | geminin | 0.0166 | 0.1148 | 0.1493 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0926 | 0.7375 | 0.959 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 0.1021 | 0.1328 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0409 | 0.314 | 0.4085 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0036 | 0.0081 | 0.0105 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.0329 | 0.0428 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.0329 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0329 | 0.0428 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.0329 | 0.0428 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0081 | 0.0105 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0964 | 0.7687 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | nuclear receptor NHR-88 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.0007 | 0.0009 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0027 | 0.0007 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0409 | 0.314 | 0.4085 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.0797 | 0.1036 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0926 | 0.7375 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0409 | 0.314 | 0.4085 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0964 | 0.7687 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0151 | 0.1021 | 0.1328 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.0007 | 0.0009 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0635 | 0.4993 | 0.5187 |
Echinococcus granulosus | geminin | 0.0166 | 0.1148 | 0.1493 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0964 | 0.7687 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 0.314 | 0.4085 |
Echinococcus multilocularis | carbonic anhydrase | 0.0409 | 0.314 | 0.4085 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 0.314 | 0.4085 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.0329 | 0.0428 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0329 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1148 | 0.1493 |
Echinococcus granulosus | carbonic anhydrase II | 0.0964 | 0.7687 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0409 | 0.314 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0926 | 0.7375 | 0.9594 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0964 | 0.7687 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | coup transcription factor | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0964 | 0.7687 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0329 | 0.0428 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0964 | 0.7687 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1246 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.0329 | 0.0428 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.0007 | 0.0009 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0027 | 0.0007 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0964 | 0.7687 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0027 | 0.0007 | 0.0009 |
Onchocerca volvulus | 0.0027 | 0.0007 | 1 | |
Echinococcus multilocularis | carbonic anhydrase II | 0.0964 | 0.7687 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0409 | 0.314 | 0.4085 |
Echinococcus granulosus | carbonic anhydrase | 0.0409 | 0.314 | 0.4085 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.0329 | 0.0428 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0036 | 0.0081 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0409 | 0.314 | 0.4085 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.0329 | 0.0428 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | FTZ F1 alpha | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0409 | 0.314 | 0.4085 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0027 | 0.0007 | 0.0009 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0964 | 0.7687 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.0007 | 0.0009 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0027 | 0.0007 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0409 | 0.314 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0027 | 0.0007 | 0.0009 |
Leishmania major | carbonic anhydrase-like protein | 0.0964 | 0.7687 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0081 | 0.0105 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.0329 | 0.0428 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 0.1021 | 0.1328 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0027 | 0.0007 | 0.0009 |
Echinococcus granulosus | carbonic anhydrase | 0.0409 | 0.314 | 0.4085 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.0797 | 0.1036 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0964 | 0.7687 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0926 | 0.7375 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0409 | 0.314 | 0.4085 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0036 | 0.0081 | 0.0105 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0036 | 0.0081 | 0.0105 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0027 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0027 | 0.0007 | 0.0009 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 0.0081 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0409 | 0.314 | 0.4085 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0027 | 0.0007 | 0.0009 |
Echinococcus multilocularis | carbonic anhydrase | 0.0409 | 0.314 | 0.4085 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0027 | 0.0007 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0797 | 0.1036 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0027 | 0.0007 | 0.0009 |
Brugia malayi | nuclear hormone receptor | 0.0027 | 0.0007 | 0.0009 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0955 | 0.7618 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0105 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.0329 | 0.0428 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of PAF-induced platelet aggregation (unknown origin) | ChEMBL. | 17650015 |
Activity (functional) | 0 | Inhibition of ADP-induced platelet aggregation (unknown origin) | ChEMBL. | 17650015 |
Activity (functional) | 0 | Inhibition of AA-induced platelet aggregation (unknown origin) | ChEMBL. | 17650015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.