Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0097 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0097 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0097 | 0.0007 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0093 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0191 | 0.0101 |
Brugia malayi | hypothetical protein | 0.0318 | 0.1119 | 0.0946 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0093 | 0.0191 | 0.5 |
Echinococcus granulosus | Solute carrier family 22 5 | 0.1011 | 0.3976 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0093 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0191 | 0.0101 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0692 | 0.2662 | 0.6528 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0097 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0191 | 0.0101 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0093 | 0.0191 | 0.0716 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.2472 | 1 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0093 | 0.0191 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0692 | 0.2662 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0692 | 0.2662 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0097 | 0.0007 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0692 | 0.2662 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0097 | 0.0007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 15 mM | Antibacterial activity against Proteus vulgaris at pH 7 | ChEMBL. | 17689076 |
MIC (functional) | = 15 mM | Antibacterial activity against Proteus vulgaris at pH 6 | ChEMBL. | 17689076 |
MIC (functional) | = 20 mM | Antibacterial activity against Proteus mirabilis at pH 7 | ChEMBL. | 17689076 |
MIC (functional) | = 20 mM | Antibacterial activity against Proteus vulgaris at pH 5 | ChEMBL. | 17689076 |
MIC (functional) | = 25 mM | Antibacterial activity against Escherichia coli at pH 7 | ChEMBL. | 17689076 |
MIC (functional) | = 25 mM | Antibacterial activity against Pseudomonas aeruginosa at pH 7 | ChEMBL. | 17689076 |
MIC (functional) | = 25 mM | Antibacterial activity against Escherichia coli at pH 5 | ChEMBL. | 17689076 |
MIC (functional) | = 25 mM | Antibacterial activity against Escherichia coli at pH 7 | ChEMBL. | 17689076 |
MIC (functional) | = 25 mM | Antibacterial activity against Escherichia coli at pH 5 | ChEMBL. | 17689076 |
MIC (functional) | = 40 mM | Antibacterial activity against Pseudomonas aeruginosa at pH 6 | ChEMBL. | 17689076 |
MIC (functional) | = 45 mM | Antibacterial activity against Proteus mirabilis at pH 5 | ChEMBL. | 17689076 |
MIC (functional) | = 50 mM | Antibacterial activity against Escherichia coli at pH 6 | ChEMBL. | 17689076 |
MIC (functional) | = 50 mM | Antibacterial activity against Escherichia coli at pH 6 | ChEMBL. | 17689076 |
MIC (functional) | = 75 mM | Antibacterial activity against Proteus mirabilis at pH 6 | ChEMBL. | 17689076 |
MIC (functional) | = 75 mM | Antibacterial activity against Pseudomonas aeruginosa at pH 5 | ChEMBL. | 17689076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.