Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | 0.0167 | 0.3023 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0167 | 0.3023 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0167 | 0.3023 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0167 | 0.3023 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0 | 0.5 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.0487 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.0487 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.3023 | 1 |
Plasmodium vivax | amine transporter, putative | 0.0028 | 0 | 0.5 |
Plasmodium falciparum | amino acid transporter, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0167 | 0.3023 | 1 |
Plasmodium falciparum | transporter, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.3023 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0167 | 0.3023 | 1 |
Onchocerca volvulus | 0.0167 | 0.3023 | 1 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0167 | 0.3023 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.3023 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0167 | 0.3023 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0167 | 0.3023 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.3 uM | Cytotoxicity against human HCT116 cells | ChEMBL. | 18178085 |
IC50 (functional) | = 6.3 uM | Cytotoxicity against human HCT116 cells | ChEMBL. | 18178085 |
IC50 (functional) | > 50 uM | Cytotoxicity against human DU145 cells | ChEMBL. | 18178085 |
IC50 (functional) | > 50 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 18178085 |
IC50 (functional) | > 50 uM | Cytotoxicity against human MDA-MB231 cells | ChEMBL. | 18178085 |
IC50 (functional) | > 50 uM | Cytotoxicity against human HL60 cells | ChEMBL. | 18178085 |
IC50 (functional) | > 50 uM | Cytotoxicity against human DU145 cells | ChEMBL. | 18178085 |
IC50 (functional) | > 50 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 18178085 |
IC50 (functional) | > 50 uM | Cytotoxicity against human MDA-MB231 cells | ChEMBL. | 18178085 |
IC50 (functional) | > 50 uM | Cytotoxicity against human HL60 cells | ChEMBL. | 18178085 |
Inhibition (binding) | = 0.5 % | Inhibition of human topoisomerase 2alpha assessed as relaxation of supercoiled DNA pBR322 at 2 uM relative to etoposide | ChEMBL. | 18178085 |
Inhibition (binding) | = 0.5 % | Inhibition of human topoisomerase 2alpha assessed as relaxation of supercoiled DNA pBR322 at 2 uM relative to etoposide | ChEMBL. | 18178085 |
Inhibition (binding) | = 53.5 % | Inhibition of calf thymus topoisomerase 1 assessed as relaxation of supercoiled DNA pBR322 at 2 uM relative to etoposide | ChEMBL. | 18178085 |
Inhibition (binding) | = 82.4 % | Inhibition of human topoisomerase 2alpha assessed as relaxation of supercoiled DNA pBR322 at 10 uM relative to etoposide | ChEMBL. | 18178085 |
Inhibition (binding) | = 82.4 % | Inhibition of human topoisomerase 2alpha assessed as relaxation of supercoiled DNA pBR322 at 10 uM relative to etoposide | ChEMBL. | 18178085 |
Inhibition (binding) | = 96.6 % | Inhibition of calf thymus topoisomerase 1 assessed as relaxation of supercoiled DNA pBR322 at 20 uM relative to etoposide | ChEMBL. | 18178085 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18178085 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.