Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.8353 | 1 |
Trypanosoma brucei | unspecified product | 0.0024 | 0.1385 | 0.1362 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0024 | 0.1385 | 0.1362 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0072 | 0.8353 | 1 |
Chlamydia trachomatis | two component regulatory system response regulator/ATPase | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.111 | 0.111 |
Giardia lamblia | Ribonuclease H | 0.0022 | 0.111 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0024 | 0.1385 | 0.1362 |
Echinococcus granulosus | ribonuclease H1 | 0.0022 | 0.111 | 0.5 |
Leishmania major | ribonuclease H1, putative | 0.0022 | 0.111 | 1 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0022 | 0.111 | 1 |
Brugia malayi | RNase H family protein | 0.0022 | 0.111 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.8353 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0022 | 0.111 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0022 | 0.111 | 1 |
Brugia malayi | RNase H family protein | 0.0022 | 0.111 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0072 | 0.8353 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.111 | 0.111 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.0026 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0084 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.0026 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0022 | 0.111 | 1 |
Trypanosoma brucei | ribonuclease H1 | 0.0022 | 0.111 | 0.1087 |
Brugia malayi | RNase H family protein | 0.0022 | 0.111 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0024 | 0.1385 | 0.1362 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0022 | 0.111 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0022 | 0.111 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0022 | 0.111 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.1385 | 0.1362 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.111 | 0.111 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0.0026 | 1 |
Echinococcus multilocularis | ribonuclease H1 | 0.0022 | 0.111 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.0026 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.7 nM | Inhibition of gamma secretase (unknown origin) assessed as membrane Amyloid beta 40 level | ChEMBL. | 17988864 |
IC50 (binding) | = 65 nM | Inhibition of gamma secretase (unknown origin) assessed as cellular Amyloid beta 40 level | ChEMBL. | 17988864 |
IC50 (ADMET) | = 5 uM | Inhibition of CYP3A4 (unknown origin) preincubated before 30 mins | ChEMBL. | 17988864 |
IC50 (ADMET) | = 5 uM | Inhibition of CYP3A4 (unknown origin) preincubated before 30 mins | ChEMBL. | 17988864 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.