Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.4892 | 0.193 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0301 | 0.8314 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0208 | 0.5244 | 0.2759 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.4074 | 0.0332 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.3871 | 0.3871 |
Brugia malayi | hypothetical protein | 0.0127 | 0.2574 | 0.1952 |
Echinococcus granulosus | snurportin 1 | 0.032 | 0.8942 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0301 | 0.8314 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.032 | 0.8942 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0185 | 0.4493 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0208 | 0.5244 | 0.2759 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0352 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.4892 | 0.193 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0173 | 0.4074 | 0.4056 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0241 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0301 | 0.8314 | 0.9014 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0167 | 0.3871 | 0.3871 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.4074 | 0.2356 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0301 | 0.8314 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0301 | 0.8314 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.4074 | 0.4074 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.4892 | 0.193 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0301 | 0.8314 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.4892 | 0.193 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0198 | 0.4892 | 1 |
Schistosoma mansoni | hypothetical protein | 0.032 | 0.8942 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.4074 | 0.4074 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.4892 | 0.193 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.0358 | 0.0358 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.4074 | 0.4074 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.4892 | 0.193 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.4074 | 0.4074 |
Onchocerca volvulus | 0.0173 | 0.4074 | 0.6471 | |
Echinococcus multilocularis | snurportin 1 | 0.032 | 0.8942 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.4892 | 0.193 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0301 | 0.8314 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0301 | 0.8314 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0185 | 0.4493 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
Efficacy (functional) | = 0 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
Efficacy (functional) | = 0 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
Efficacy (functional) | = 6.3 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
Efficacy (functional) | = 6.3 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human MAGL mediated [14C]2-AG hydrolysis in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (functional) | > 25 uM | Inhibition of [14C]anandamide uptake in rat RBL-2H3 | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.