Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0422 | 0.7375 | 0.7073 |
Chlamydia trachomatis | glutamine binding protein | 0.0097 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0097 | 0 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.103 | 0.0185 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0422 | 0.7375 | 0.7127 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0097 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0402 | 0.6933 | 0.6581 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0537 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0097 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0097 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0402 | 0.6933 | 0.6645 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0097 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.103 | 0.1191 |
Schistosoma mansoni | glutamate receptor NMDA | 0.046 | 0.8235 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | < 0.1 ug ml-1 | LPO-lowering activity was estimated by the IC50 value of compound in rat liver microsomal lipid peroxidation | ChEMBL. | 2329571 |
IC50 (functional) | < 0.1 ug ml-1 | In vitro inhibitory activity against rat microsomal lipid peroxidation (m-LPO) | ChEMBL. | 2913302 |
IC50 (functional) | = 0.29 uM | Evaluated for inhibition of the formation and release of 5-lipoxygenase in isolated guinea pig ileum | ChEMBL. | 2329571 |
IC50 (functional) | = 0.29 uM | Evaluated for inhibition of the formation and release of 5-lipoxygenase in isolated guinea pig ileum | ChEMBL. | 2329571 |
IC50 (functional) | = 2.4 uM | Evaluated for inhibition of the formation and release of SRS-A in isolated guinea pig ileum | ChEMBL. | 2329571 |
Q1/2 (functional) | = 1.3 mM | The concntration of compound required to inhibit generation of superoxide by 50 percent in rat liver | ChEMBL. | 2329571 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.