Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0309 | 0.0309 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0056 | 0.3935 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.004 | 0.1813 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.004 | 0.1813 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0059 | 0.4461 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0059 | 0.4461 | 1 |
Toxoplasma gondii | methionine aminopeptidase | 0.004 | 0.1813 | 0.4064 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0059 | 0.4461 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0059 | 0.4461 | 1 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0059 | 0.4461 | 0.4461 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0059 | 0.4461 | 1 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.004 | 0.1813 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0059 | 0.4461 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0059 | 0.4461 | 0.4461 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0056 | 0.3935 | 0.882 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0059 | 0.4461 | 1 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0056 | 0.3935 | 0.8012 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0056 | 0.3935 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.004 | 0.1813 | 0.5 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0059 | 0.4461 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.004 | 0.1813 | 0.5 |
Treponema pallidum | methionine aminopeptidase (map) | 0.004 | 0.1813 | 1 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0056 | 0.3935 | 0.8012 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0059 | 0.4461 | 1 |
Brugia malayi | initiation factor 2-associated protein. | 0.0056 | 0.3935 | 0.882 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0059 | 0.4461 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0029 | 0.0309 | 0.0309 |
Giardia lamblia | Methionine aminopeptidase | 0.0056 | 0.3935 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0056 | 0.3935 | 0.3935 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0056 | 0.3935 | 0.882 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0309 | 0.0309 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0056 | 0.3935 | 0.3935 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0056 | 0.3935 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0056 | 0.3935 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.004 | 0.1813 | 0.4064 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.004 | 0.1813 | 0.1813 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.004 | 0.1813 | 0.1813 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0056 | 0.3935 | 1 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.004 | 0.1813 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0056 | 0.3935 | 0.882 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.004 | 0.1813 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0056 | 0.3935 | 0.882 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0056 | 0.3935 | 0.882 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0056 | 0.3935 | 0.3935 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0059 | 0.4461 | 0.4461 |
Chlamydia trachomatis | methionine aminopeptidase | 0.004 | 0.1813 | 0.5 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0056 | 0.3935 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.0309 | 0.0309 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.004 | 0.1813 | 0.4064 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0309 | 0.0309 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0056 | 0.3935 | 0.882 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 10 uM | Cytotoxic concentration against MT-2 cells | ChEMBL. | 7684450 |
CC50 (functional) | > 10 uM | Cytotoxic concentration against PBMC cells | ChEMBL. | 7684450 |
CC50 (functional) | > 10 uM | Cytotoxic concentration against MT-2 cells | ChEMBL. | 7684450 |
ED50 (functional) | = 0.01 uM | Inhibition of HIV-1 replication in human lymphocytes [peripheral blood mononuclear cells (PBMC)/D34 was determined as effective dose | ChEMBL. | 7684450 |
ED50 (functional) | = 0.27 uM | Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells. | ChEMBL. | 7684450 |
IC50 (binding) | = 2 uM | In vitro inhibition of HIV-1 reverse transcriptase | ChEMBL. | 7684450 |
IC50 (binding) | = 2 uM | In vitro inhibition of HIV-1 reverse transcriptase | ChEMBL. | 7684450 |
Inhibition (binding) | = 89 % | In vitro inhibition of HIV-1 reverse transcriptase at 100 microM | ChEMBL. | 7684450 |
Inhibition (binding) | = 89 % | In vitro inhibition of HIV-1 reverse transcriptase at 100 microM | ChEMBL. | 7684450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.