Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3161 | 0.2923 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.3292 | 0.3059 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0799 | 0.096 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0799 | 0.0479 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0087 | 0.4491 | 0.4299 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0799 | 0.0479 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.3292 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0799 | 0.1547 | |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.1799 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.3477 | 0.3249 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.3161 | 0.3794 |
Loa Loa (eye worm) | doublecortin family protein | 0.002 | 0.0336 | 0.0404 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0039 | 0.1473 | 0.1176 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.1799 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.1517 | 0.1222 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 0.3292 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 0.3292 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.1799 | 0.1513 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.3161 | 0.3794 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0087 | 0.4491 | 0.4299 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0068 | 0.3292 | 0.3952 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3161 | 0.2923 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.1799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0768 | 0.0922 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0799 | 0.0479 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.3161 | 0.3794 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.1572 | 1 |
Echinococcus multilocularis | geminin | 0.0176 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0039 | 0.1473 | 0.1176 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.3161 | 0.2923 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.3161 | 0.3794 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.1572 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.0799 | 0.0479 |
Loa Loa (eye worm) | acetyltransferase | 0.0149 | 0.8331 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.3161 | 0.2923 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0799 | 0.0479 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3161 | 0.2923 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.3161 | 0.3794 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.3292 | 0.3952 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0121 | 0.6607 | 0.6489 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.3292 | 0.5 |
Brugia malayi | bZIP transcription factor family protein | 0.0087 | 0.4491 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0336 | 0.0404 |
Echinococcus granulosus | jun protein | 0.0087 | 0.4491 | 0.4299 |
Echinococcus multilocularis | jun protein | 0.0087 | 0.4491 | 0.4299 |
Brugia malayi | hypothetical protein | 0.002 | 0.0336 | 0.0404 |
Echinococcus granulosus | lamin | 0.0028 | 0.0799 | 0.0479 |
Brugia malayi | RNA binding protein | 0.0066 | 0.3161 | 0.3794 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3161 | 0.2923 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.1799 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.3328 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0799 | 0.096 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0799 | 0.0479 |
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.4342 | 0.4145 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0799 | 0.0479 |
Brugia malayi | hypothetical protein | 0.0069 | 0.3328 | 0.3995 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4342 | 0.5212 |
Onchocerca volvulus | 0.0028 | 0.0799 | 0.1547 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0336 | 0.0404 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.3292 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.3292 | 0.3059 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0799 | 0.096 |
Echinococcus granulosus | sodium channel protein | 0.0039 | 0.1473 | 0.1176 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.6607 | 0.6489 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0149 | 0.8331 | 0.8273 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0149 | 0.8331 | 0.8273 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0149 | 0.8331 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.8072 | 0.8004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3161 | 0.2923 |
Schistosoma mansoni | jun-related protein | 0.0071 | 0.3477 | 0.3249 |
Schistosoma mansoni | lamin | 0.0028 | 0.0799 | 0.0479 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0799 | 0.096 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.1517 | 0.1222 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.1799 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0121 | 0.6607 | 0.6489 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0799 | 0.096 |
Brugia malayi | hypothetical protein | 0.002 | 0.0336 | 0.0404 |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0336 | 0.0404 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.3292 | 0.3059 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 48 % | Inhibition of human autotaxin expressed in MDA-MB-435 cells assessed as fluorescent lysophosphatidyl choline analog hydrolysis at 10 uM | ChEMBL. | 18036821 |
Inhibition (binding) | = 48 % | Inhibition of human autotaxin expressed in MDA-MB-435 cells assessed as fluorescent lysophosphatidyl choline analog hydrolysis at 10 uM | ChEMBL. | 18036821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.