Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.1158 | 0.9483 | 1 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0143 | 0.016 | 0.0759 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0182 | 0.0517 | 0.0517 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.0143 | 0.016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.016 | 0.016 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1214 | 1 | 1 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0143 | 0.016 | 0.016 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0182 | 0.0517 | 0.2449 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0355 | 0.211 | 1 |
Onchocerca volvulus | 0.0877 | 0.6907 | 1 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0182 | 0.0517 | 0.2449 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0535 | 0.002 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0182 | 0.0517 | 0.2449 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0182 | 0.0517 | 0.2449 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0355 | 0.211 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0182 | 0.0517 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1214 | 1 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0809 | 0.6282 | 0.643 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0182 | 0.0517 | 0.2449 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0182 | 0.0517 | 0.2449 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0182 | 0.0517 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0182 | 0.0517 | 0.2449 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0182 | 0.0517 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0182 | 0.0517 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0182 | 0.0517 | 0.0362 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0182 | 0.0517 | 0.0517 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0809 | 0.6282 | 0.6282 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1214 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.1158 | 0.9483 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0809 | 0.6282 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0182 | 0.0517 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0182 | 0.0517 | 1 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0809 | 0.6282 | 0.6222 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0182 | 0.0517 | 0.2449 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0182 | 0.0517 | 0.2449 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1214 | 1 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0809 | 0.6282 | 0.6222 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0809 | 0.6282 | 0.6282 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0182 | 0.0517 | 0.0362 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0182 | 0.0517 | 1 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0143 | 0.016 | 0.0759 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0143 | 0.016 | 0.31 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.5 uM | Antagonist activity at CCR3 (unknown origin) expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx | ChEMBL. | 17951061 |
IC50 (functional) | = 3.5 uM | Antagonist activity at CCR3 (unknown origin) expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx | ChEMBL. | 17951061 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.