Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0327 | 0.2271 | 1 |
Onchocerca volvulus | 0.0327 | 0.2271 | 0.4303 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.3722 | 0.3722 |
Trypanosoma brucei | phospholipase A1, putative | 0.0327 | 0.2271 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.1105 | 0.8106 | 1 |
Leishmania major | phospholipase A1, putative | 0.0327 | 0.2271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.1711 | 0.1711 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0117 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0694 | 0.0694 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.1105 | 0.8106 | 1 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.015 | 0.0943 | 0.415 |
Onchocerca volvulus | 0.0327 | 0.2271 | 0.4303 | |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0783 | 0.5694 | 0.6746 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0117 | 0.0694 | 0.0694 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0369 | 0.2588 | 0.2588 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0 | 0.5 |
Brugia malayi | Phospholipase A2 family protein | 0.0181 | 0.1176 | 0.1176 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0252 | 0.1711 | 0.1711 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.015 | 0.0943 | 0.415 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.0327 | 0.2271 | 0.2271 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0327 | 0.2271 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.0682 | 0.0682 |
Brugia malayi | Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein | 0.0327 | 0.2271 | 0.2271 |
Schistosoma mansoni | hypothetical protein | 0.0252 | 0.1711 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1176 | 0.1176 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.0682 | 0.0682 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0521 | 0.3722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0369 | 0.2588 | 0.2588 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0117 | 0.0694 | 0.0694 |
Onchocerca volvulus | 0.0327 | 0.2271 | 0.4303 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.0682 | 0.0682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Cytotoxicity against human A549 cells after 24 hrs by MTT assay | ChEMBL. | 18356046 |
GI50 (ADMET) | = 8.35 10^-4M | Cytotoxicity against mouse RAW2647 cells after 24 hrs by MTT assay | ChEMBL. | 18356046 |
GI50 (functional) | = 13.22 10^4M | Cytotoxicity against human HT29 cells after 24 hrs by MTT assay | ChEMBL. | 18356046 |
GI50 (functional) | = 13.22 10^4M | Cytotoxicity against human HT29 cells after 24 hrs by MTT assay | ChEMBL. | 18356046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.