Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0193 | 0.4283 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0403 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Brugia malayi | beta-lactamase | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.0193 | 0.4283 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0193 | 0.4283 | 0.4283 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0193 | 0.4283 | 0.4283 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0233 | 0.5358 | 0.5358 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.013 nM | Inhibition of human factor 10a | ChEMBL. | 18329876 |
Ki (binding) | = 0.013 nM | Inhibition of human factor 10a | ChEMBL. | 18329876 |
Papp (ADMET) | = 0 10^-6 cm/s | Apparent permeability across human Caco2 cells | ChEMBL. | 18329876 |
Papp (ADMET) | = 0 10^-6 cm/s | Apparent permeability across human Caco2 cells | ChEMBL. | 18329876 |
PT (functional) | = 2.1 uM | Anticoagulant efficacy in human citrated plasma assessed as concentration required to double prothrombin time | ChEMBL. | 18329876 |
Selectivity ratio (binding) | > 1000 | Selectivity for human factor 10a over thrombin (unknown origin) | ChEMBL. | 18329876 |
Selectivity ratio (binding) | > 1000 | Selectivity for human factor 10a over trypsin (unknown origin) | ChEMBL. | 18329876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.