Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium/calmodulin-dependent protein kinase II delta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dynactin 5 p25 | 0.0071 | 0.0125 | 0.0183 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1875 | 0.686 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0926 | 0.3317 | 0.4835 |
Schistosoma mansoni | protein kinase | 0.0152 | 0.0428 | 0.0624 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0013 | 0.0018 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0926 | 0.3317 | 0.4835 |
Echinococcus granulosus | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Plasmodium falciparum | carbonic anhydrase | 0.0926 | 0.3317 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0979 | 0.3515 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0926 | 0.3317 | 0.4835 |
Trichomonas vaginalis | maltose O-acetyltransferase, putative | 0.0068 | 0.0115 | 0.0194 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0.0731 | 0.0731 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1875 | 0.686 | 1 |
Entamoeba histolytica | bacterial transferase hexapeptide family protein | 0.0041 | 0.0013 | 0.0024 |
Echinococcus multilocularis | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1426 | 0.5184 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0237 | 0.0747 | 0.1247 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1624 | 0.5922 | 1 |
Mycobacterium ulcerans | transferase | 0.0068 | 0.0115 | 0.0174 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0115 | 0.0194 |
Entamoeba histolytica | acetyltransferase, putative | 0.0071 | 0.0125 | 0.0242 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0926 | 0.3317 | 0.4835 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0133 | 0.0359 | 0.0523 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1875 | 0.686 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.1875 | 0.686 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0926 | 0.3317 | 0.4835 |
Entamoeba histolytica | ankyrin, putative | 0.0071 | 0.0125 | 0.0242 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0926 | 0.3317 | 0.3317 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0013 | 0.0018 |
Echinococcus granulosus | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1624 | 0.5922 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0882 | 0.3154 | 0.8969 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0133 | 0.0359 | 0.0359 |
Echinococcus multilocularis | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0013 | 0.0018 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0071 | 0.0125 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0926 | 0.3317 | 0.3317 |
Schistosoma mansoni | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0926 | 0.3317 | 0.4835 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1875 | 0.686 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0781 | 0.2777 | 0.7893 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0237 | 0.0747 | 0.2097 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1875 | 0.686 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0926 | 0.3317 | 0.4835 |
Toxoplasma gondii | hypothetical protein | 0.0926 | 0.3317 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0071 | 0.0125 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1875 | 0.686 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1624 | 0.5922 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0206 | 0.0628 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1426 | 0.5184 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1875 | 0.686 | 1 |
Schistosoma mansoni | protein kinase | 0.0152 | 0.0428 | 0.0624 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1875 | 0.686 | 0.686 |
Echinococcus granulosus | carbonic anhydrase II | 0.1875 | 0.686 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0071 | 0.0125 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0926 | 0.3317 | 0.4835 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0.0731 | 0.1066 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0152 | 0.0428 | 0.0624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0013 | 0.0018 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1426 | 0.5184 | 0.8751 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0152 | 0.0428 | 0.0624 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1875 | 0.686 | 0.686 |
Loa Loa (eye worm) | hypothetical protein | 0.0926 | 0.3317 | 0.3317 |
Schistosoma mansoni | protein kinase | 0.0152 | 0.0428 | 0.0624 |
Echinococcus multilocularis | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1875 | 0.686 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1426 | 0.5184 | 0.7557 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1426 | 0.5184 | 0.7557 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0926 | 0.3317 | 0.4835 |
Onchocerca volvulus | 0.0206 | 0.0628 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.