Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium/calmodulin-dependent protein kinase II delta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0152 | 0.0428 | 0.0624 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1875 | 0.686 | 0.686 |
Loa Loa (eye worm) | hypothetical protein | 0.0926 | 0.3317 | 0.3317 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1426 | 0.5184 | 0.8751 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0152 | 0.0428 | 0.0624 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0.0731 | 0.1066 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0152 | 0.0428 | 0.0624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0013 | 0.0018 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0926 | 0.3317 | 0.4835 |
Onchocerca volvulus | 0.0206 | 0.0628 | 1 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0926 | 0.3317 | 0.4835 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1426 | 0.5184 | 0.7557 |
Schistosoma mansoni | carbonic anhydrase | 0.1426 | 0.5184 | 0.7557 |
Echinococcus multilocularis | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1875 | 0.686 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0071 | 0.0125 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0926 | 0.3317 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1875 | 0.686 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0926 | 0.3317 | 0.4835 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0237 | 0.0747 | 0.2097 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0781 | 0.2777 | 0.7893 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0926 | 0.3317 | 0.4835 |
Schistosoma mansoni | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1875 | 0.686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0926 | 0.3317 | 0.3317 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0071 | 0.0125 | 0.0322 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0013 | 0.0018 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0071 | 0.0125 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.1875 | 0.686 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1875 | 0.686 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1875 | 0.686 | 0.686 |
Schistosoma mansoni | protein kinase | 0.0152 | 0.0428 | 0.0624 |
Echinococcus granulosus | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1426 | 0.5184 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1875 | 0.686 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1624 | 0.5922 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0206 | 0.0628 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1624 | 0.5922 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0926 | 0.3317 | 0.3317 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0013 | 0.0018 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0926 | 0.3317 | 0.4835 |
Entamoeba histolytica | ankyrin, putative | 0.0071 | 0.0125 | 0.0242 |
Leishmania major | carbonic anhydrase-like protein | 0.1875 | 0.686 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0133 | 0.0359 | 0.0359 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0882 | 0.3154 | 0.8969 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1426 | 0.5184 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0237 | 0.0747 | 0.1247 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1875 | 0.686 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0.0731 | 0.0731 |
Entamoeba histolytica | bacterial transferase hexapeptide family protein | 0.0041 | 0.0013 | 0.0024 |
Trichomonas vaginalis | maltose O-acetyltransferase, putative | 0.0068 | 0.0115 | 0.0194 |
Echinococcus granulosus | carbonic anhydrase | 0.0926 | 0.3317 | 0.4835 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0979 | 0.3515 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0926 | 0.3317 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0926 | 0.3317 | 0.4835 |
Schistosoma mansoni | protein kinase | 0.0152 | 0.0428 | 0.0624 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0013 | 0.0018 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0926 | 0.3317 | 0.4835 |
Schistosoma mansoni | hypothetical protein | 0.0926 | 0.3317 | 0.4835 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1875 | 0.686 | 1 |
Echinococcus granulosus | dynactin 5 p25 | 0.0071 | 0.0125 | 0.0183 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1875 | 0.686 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0926 | 0.3317 | 0.4835 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0133 | 0.0359 | 0.0523 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0115 | 0.0194 |
Entamoeba histolytica | acetyltransferase, putative | 0.0071 | 0.0125 | 0.0242 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1624 | 0.5922 | 1 |
Mycobacterium ulcerans | transferase | 0.0068 | 0.0115 | 0.0174 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.